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Virginia L. Miller

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Virginia Miller
At the 2022 Microbe annual meeting
Alma mater
Scientific career
Institutions
ThesisAnalysis of the cholera toxin positive regulatory gene, toxR (1985)

Virginia L. Miller is a microbiologist known for her work on studying the factors leading to disease caused by bacteria. Miller is an elected fellow of the American Academy of Microbiology (2003) and a former Pew Charitable Trust Biomedical Scholar (1989).[1]

Education and career

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Miller has a B.A. from the University of California, Santa Barbara (1979).[2] She earned her Ph.D. from Harvard University in 1985 where she worked on the expression of genes associated with Cholera toxin.[3] Following her Ph.D., she was a postdoc at Stanford University.[4] She moved to the University of California, Los Angeles in 1988 and earned tenure in 1994.[5] She moved to Washington University in St. Louis in 1996, and then to the University of North Carolina at Chapel Hill in 2008.[4] As of 2021, Miller is a professor of genetics, microbiology, and immunology at the University of North Carolina at Chapel Hill.[2]

Research

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Miller is known for her research into bacterial pathogenesis, the factors leading to the onset of disease from specific species of bacteria.[6][7][8][9][10] Her early research examined the synthesis of the cholera toxin by Vibrio cholerae[11][12] and identified environmental signals that lead V. cholerae to express the proteins needed to make the cholera toxin.[13] She went on to examine the mechanisms by which another bacteria pathogen - Yersinia pestis - enters cells[14] and cause disease.[15] She has also worked on how Salmonella[16][17] and Klebsiella pneumoniae[18][19] cause disease. In brief, she mostly worked in the areas of Microbiology, Yersinia enterocolitica and Virulence.[20]

Awards and honors

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In 1989, Miller was named a Pew Scholar.[1] In 2003, Miller was elected a fellow of the American Academy of Microbiology.[21][5]

Selected publications

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  • Miller, Virginia L.; Taylor, Ronald K.; Mekalanos, John J. (1987-01-30). "Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein". Cell. 48 (2): 271–279. doi:10.1016/0092-8674(87)90430-2. ISSN 0092-8674. PMID 3802195. S2CID 28576010.271-279&rft.date=1987-01-30&rft.issn=0092-8674&rft_id=https://api.semanticscholar.org/CorpusID:28576010#id-name=S2CID&rft_id=info:pmid/3802195&rft_id=info:doi/10.1016/0092-8674(87)90430-2&rft.aulast=Miller&rft.aufirst=Virginia L.&rft.au=Taylor, Ronald K.&rft.au=Mekalanos, John J.&rft_id=https://www.cell.com/cell/abstract/0092-8674(87)90430-2&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  • Miller, V L; Mekalanos, J J (1988-06-01). "A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR". Journal of Bacteriology. 170 (6): 2575–2583. doi:10.1128/jb.170.6.2575-2583.1988. PMC 211174. PMID 2836362.2575-2583&rft.date=1988-06-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC211174#id-name=PMC&rft_id=info:pmid/2836362&rft_id=info:doi/10.1128/jb.170.6.2575-2583.1988&rft.aulast=Miller&rft.aufirst=V L&rft.au=Mekalanos, J J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC211174&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  • Taylor, R. K.; Miller, V. L.; Furlong, D. B.; Mekalanos, J. J. (1987-05-01). "Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin". Proceedings of the National Academy of Sciences. 84 (9): 2833–2837. Bibcode:1987PNAS...84.2833T. doi:10.1073/pnas.84.9.2833. ISSN 0027-8424. PMC 304754. PMID 2883655.2833-2837&rft.date=1987-05-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304754#id-name=PMC&rft_id=info:bibcode/1987PNAS...84.2833T&rft_id=info:pmid/2883655&rft_id=info:doi/10.1073/pnas.84.9.2833&rft.issn=0027-8424&rft.aulast=Taylor&rft.aufirst=R. K.&rft.au=Miller, V. L.&rft.au=Furlong, D. B.&rft.au=Mekalanos, J. J.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC304754&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">

References

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  1. ^ a b "Virginia L. Miller, PhD". PEW Trusts - Biomedical Scholars (1989). Retrieved 2022-03-16.
  2. ^ a b "Virginia Miller, PhD". Institute for Global Health and Infectious Diseases. Retrieved 2021-12-04.
  3. ^ Miller, Virginia L (1985). Analysis of the cholera toxin positive regulatory gene, toxR (Thesis). OCLC 17572198.
  4. ^ a b "Virginia Miller, Ph.D." ASM.org. Retrieved 2021-11-30.
  5. ^ a b "Miller biographical sketch" (PDF). 2014-02-23. Archived (PDF) from the original on 2014-02-23. Retrieved 2021-12-04.
  6. ^ Schmiel, Deborah H.; Miller, Virginia L. (1999-11-01). "Bacterial phospholipases and pathogenesis". Microbes and Infection. 1 (13): 1103–1112. doi:10.1016/S1286-4579(99)00205-1. ISSN 1286-4579. PMID 10572314.1103-1112&rft.date=1999-11-01&rft.issn=1286-4579&rft_id=info:pmid/10572314&rft_id=info:doi/10.1016/S1286-4579(99)00205-1&rft.aulast=Schmiel&rft.aufirst=Deborah H.&rft.au=Miller, Virginia L.&rft_id=https://doi.org/10.1016%2FS1286-4579%2899%2900205-1&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  7. ^ Pepe, J C; Wachtel, M R; Wagar, E; Miller, V L (December 1995). "Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB/c mouse model of infection". Infection and Immunity. 63 (12): 4837–4848. doi:10.1128/iai.63.12.4837-4848.1995. ISSN 0019-9567. PMC 173693. PMID 7591144.4837-4848&rft.date=1995-12&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC173693#id-name=PMC&rft.issn=0019-9567&rft_id=info:pmid/7591144&rft_id=info:doi/10.1128/iai.63.12.4837-4848.1995&rft.aulast=Pepe&rft.aufirst=J C&rft.au=Wachtel, M R&rft.au=Wagar, E&rft.au=Miller, V L&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC173693&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  8. ^ Young, Glenn M.; Miller, Virginia L. (July 1997). "Identification of novel chromosomal loci affecting Yersinia enterocolitica pathogenesis". Molecular Microbiology. 25 (2): 319–328. doi:10.1046/j.1365-2958.1997.4661829.x. PMID 9282744. S2CID 25748196.319-328&rft.date=1997-07&rft_id=https://api.semanticscholar.org/CorpusID:25748196#id-name=S2CID&rft_id=info:pmid/9282744&rft_id=info:doi/10.1046/j.1365-2958.1997.4661829.x&rft.aulast=Young&rft.aufirst=Glenn M.&rft.au=Miller, Virginia L.&rft_id=https://doi.org/10.1046%2Fj.1365-2958.1997.4661829.x&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  9. ^ Young, G M; Amid, D; Miller, V L (November 1996). "A bifunctional urease enhances survival of pathogenic Yersinia enterocolitica and Morganella morganii at low pH". Journal of Bacteriology. 178 (22): 6487–6495. doi:10.1128/jb.178.22.6487-6495.1996. ISSN 0021-9193. PMC 178535. PMID 8932305.6487-6495&rft.date=1996-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC178535#id-name=PMC&rft.issn=0021-9193&rft_id=info:pmid/8932305&rft_id=info:doi/10.1128/jb.178.22.6487-6495.1996&rft.aulast=Young&rft.aufirst=G M&rft.au=Amid, D&rft.au=Miller, V L&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC178535&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  10. ^ Weening, Eric H.; Cathelyn, Jason S.; Kaufman, Greer; Lawrenz, Matthew B.; Price, Paul; Goldman, William E.; Miller, Virginia L. (February 2011). Camilli, A. (ed.). "The Dependence of the Yersinia pestis Capsule on Pathogenesis Is Influenced by the Mouse Background". Infection and Immunity. 79 (2): 644–652. doi:10.1128/IAI.00981-10. ISSN 0019-9567. PMC 3028848. PMID 21115720.644-652&rft.date=2011-02&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028848#id-name=PMC&rft.issn=0019-9567&rft_id=info:pmid/21115720&rft_id=info:doi/10.1128/IAI.00981-10&rft.aulast=Weening&rft.aufirst=Eric H.&rft.au=Cathelyn, Jason S.&rft.au=Kaufman, Greer&rft.au=Lawrenz, Matthew B.&rft.au=Price, Paul&rft.au=Goldman, William E.&rft.au=Miller, Virginia L.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028848&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  11. ^ Miller, V. L.; Mekalanos, J. J. (1984-06-01). "Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR". Proceedings of the National Academy of Sciences. 81 (11): 3471–3475. Bibcode:1984PNAS...81.3471M. doi:10.1073/pnas.81.11.3471. ISSN 0027-8424. PMC 345530. PMID 6374658.3471-3475&rft.date=1984-06-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC345530#id-name=PMC&rft_id=info:bibcode/1984PNAS...81.3471M&rft_id=info:pmid/6374658&rft_id=info:doi/10.1073/pnas.81.11.3471&rft.issn=0027-8424&rft.aulast=Miller&rft.aufirst=V. L.&rft.au=Mekalanos, J. J.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC345530&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  12. ^ Miller, Virginia L.; Taylor, Ronald K.; Mekalanos, John J. (1987). "Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein". Cell. 48 (2): 271–279. doi:10.1016/0092-8674(87)90430-2. PMID 3802195. S2CID 28576010.271-279&rft.date=1987&rft_id=https://api.semanticscholar.org/CorpusID:28576010#id-name=S2CID&rft_id=info:pmid/3802195&rft_id=info:doi/10.1016/0092-8674(87)90430-2&rft.aulast=Miller&rft.aufirst=Virginia L.&rft.au=Taylor, Ronald K.&rft.au=Mekalanos, John J.&rft_id=https://linkinghub.elsevier.com/retrieve/pii/0092867487904302&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  13. ^ Miller, V L; Mekalanos, J J (1988-06-01). "A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR". Journal of Bacteriology. 170 (6): 2575–2583. doi:10.1128/jb.170.6.2575-2583.1988. PMC 211174. PMID 2836362.2575-2583&rft.date=1988-06-01&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC211174#id-name=PMC&rft_id=info:pmid/2836362&rft_id=info:doi/10.1128/jb.170.6.2575-2583.1988&rft.aulast=Miller&rft.aufirst=V L&rft.au=Mekalanos, J J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC211174&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  14. ^ Miller, V L; Falkow, S (1988). "Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells". Infection and Immunity. 56 (5): 1242–1248. doi:10.1128/iai.56.5.1242-1248.1988. ISSN 0019-9567. PMC 259798. PMID 2833444.1242-1248&rft.date=1988&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC259798#id-name=PMC&rft.issn=0019-9567&rft_id=info:pmid/2833444&rft_id=info:doi/10.1128/iai.56.5.1242-1248.1988&rft.aulast=Miller&rft.aufirst=V L&rft.au=Falkow, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC259798&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  15. ^ Miller, V L; Farmer, J J; Hill, W E; Falkow, S (1989). "The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease". Infection and Immunity. 57 (1): 121–131. doi:10.1128/iai.57.1.121-131.1989. ISSN 0019-9567. PMC 313052. PMID 2642465.121-131&rft.date=1989&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC313052#id-name=PMC&rft.issn=0019-9567&rft_id=info:pmid/2642465&rft_id=info:doi/10.1128/iai.57.1.121-131.1989&rft.aulast=Miller&rft.aufirst=V L&rft.au=Farmer, J J&rft.au=Hill, W E&rft.au=Falkow, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC313052&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  16. ^ Hong, K. Heran; Miller, Virginia L. (1998). "Identification of a Novel Salmonella Invasion Locus Homologous to Shigella ipgDE". Journal of Bacteriology. 180 (7): 1793–1802. doi:10.1128/JB.180.7.1793-1802.1998. ISSN 0021-9193. PMC 107092. PMID 9537377.1793-1802&rft.date=1998&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC107092#id-name=PMC&rft.issn=0021-9193&rft_id=info:pmid/9537377&rft_id=info:doi/10.1128/JB.180.7.1793-1802.1998&rft.aulast=Hong&rft.aufirst=K. Heran&rft.au=Miller, Virginia L.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC107092&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  17. ^ Darwin, K. Heran; Miller, Virginia L. (1999). "Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa". Clinical Microbiology Reviews. 12 (3): 405–428. doi:10.1128/CMR.12.3.405. ISSN 0893-8512. PMC 100246. PMID 10398673.405-428&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100246#id-name=PMC&rft.issn=0893-8512&rft_id=info:pmid/10398673&rft_id=info:doi/10.1128/CMR.12.3.405&rft.aulast=Darwin&rft.aufirst=K. Heran&rft.au=Miller, Virginia L.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100246&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  18. ^ Lawlor, Matthew S.; Hsu, James; Rick, Paul D.; Miller, Virginia L. (2005). "Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model: Klebsiella pneumoniae intranasal STM". Molecular Microbiology. 58 (4): 1054–1073. doi:10.1111/j.1365-2958.2005.04918.x. PMID 16262790. S2CID 44666800.1054-1073&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:44666800#id-name=S2CID&rft_id=info:pmid/16262790&rft_id=info:doi/10.1111/j.1365-2958.2005.04918.x&rft.aulast=Lawlor&rft.aufirst=Matthew S.&rft.au=Hsu, James&rft.au=Rick, Paul D.&rft.au=Miller, Virginia L.&rft_id=https://doi.org/10.1111%2Fj.1365-2958.2005.04918.x&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  19. ^ Lawlor, Matthew S.; O'Connor, Christopher; Miller, Virginia L. (2007). "Yersinia bactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection". Infection and Immunity. 75 (3): 1463–1472. doi:10.1128/IAI.00372-06. ISSN 0019-9567. PMC 1828572. PMID 17220312.1463-1472&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828572#id-name=PMC&rft.issn=0019-9567&rft_id=info:pmid/17220312&rft_id=info:doi/10.1128/IAI.00372-06&rft.aulast=Lawlor&rft.aufirst=Matthew S.&rft.au=O'Connor, Christopher&rft.au=Miller, Virginia L.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828572&rfr_id=info:sid/en.wikipedia.org:Virginia L. Miller" class="Z3988">
  20. ^ "Virginia L. Miller: H-index & Awards - Academic Profile". Research.com. Retrieved 2022-07-29.
  21. ^ "American Academy of Microbiology fellows". Retrieved December 3, 2021.
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