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Tight junction protein ZO-2

From Wikipedia, the free encyclopedia
TJP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTJP2, C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, Tight junction protein 2, FHCA1
External IDsOMIM: 607709; MGI: 1341872; HomoloGene: 3541; GeneCards: TJP2; OMA:TJP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9414

21873

Ensembl

ENSG00000119139

ENSMUSG00000024812

UniProt

Q9UDY2

Q9Z0U1

RefSeq (mRNA)

NM_001198985
NM_011597
NM_001360391
NM_001360392
NM_001376368

RefSeq (protein)

NP_001163885
NP_001163886
NP_001163887
NP_004808
NP_963923

NP_001185914
NP_035727
NP_001347320
NP_001347321

Location (UCSC)Chr 9: 69.12 – 69.27 MbChr 19: 24.07 – 24.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.[5]

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].[6]

Interactions

[edit]

Tight junction protein 2 has been shown to interact with tight junction protein 1,[7][8][9] band 4.1,[10] occludin[7][8][11] and USP53.[12]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119139 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024812 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M (November 1994). "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb". Hum Mol Genet. 3 (6): 909–914. doi:10.1093/hmg/3.6.909. PMID 7951235.909-914&rft.date=1994-11&rft_id=info:doi/10.1093/hmg/3.6.909&rft_id=info:pmid/7951235&rft.aulast=Duclos&rft.aufirst=F&rft.au=Rodius, F&rft.au=Wrogemann, K&rft.au=Mandel, JL&rft.au=Koenig, M&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  6. ^ "Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)".
  7. ^ a b Itoh, M; Morita K; Tsukita S (February 1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. ISSN 0021-9258. PMID 10026224.5981-5986&rft.date=1999-02&rft.issn=0021-9258&rft_id=info:pmid/10026224&rft_id=info:doi/10.1074/jbc.274.9.5981&rft.aulast=Itoh&rft.aufirst=M&rft.au=Morita K&rft.au=Tsukita S&rft_id=https://doi.org/10.1074%2Fjbc.274.9.5981&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  8. ^ a b Wittchen, E S; Haskins J; Stevenson B R (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.35179-35185&rft.date=1999-12&rft.issn=0021-9258&rft_id=info:pmid/10575001&rft_id=info:doi/10.1074/jbc.274.49.35179&rft.aulast=Wittchen&rft.aufirst=E S&rft.au=Haskins J&rft.au=Stevenson B R&rft_id=https://doi.org/10.1074%2Fjbc.274.49.35179&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  9. ^ Fanning, A S; Jameson B J; Jesaitis L A; Anderson J M (November 1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton". J. Biol. Chem. 273 (45): 29745–29753. doi:10.1074/jbc.273.45.29745. ISSN 0021-9258. PMID 9792688.29745-29753&rft.date=1998-11&rft.issn=0021-9258&rft_id=info:pmid/9792688&rft_id=info:doi/10.1074/jbc.273.45.29745&rft.aulast=Fanning&rft.aufirst=A S&rft.au=Jameson B J&rft.au=Jesaitis L A&rft.au=Anderson J M&rft_id=https://doi.org/10.1074%2Fjbc.273.45.29745&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  10. ^ Mattagajasingh, S N; Huang S C; Hartenstein J S; Benz E J (September 2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. ISSN 0021-9258. PMID 10874042.30573-30585&rft.date=2000-09&rft.issn=0021-9258&rft_id=info:pmid/10874042&rft_id=info:doi/10.1074/jbc.M004578200&rft.aulast=Mattagajasingh&rft.aufirst=S N&rft.au=Huang S C&rft.au=Hartenstein J S&rft.au=Benz E J&rft_id=https://doi.org/10.1074%2Fjbc.M004578200&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  11. ^ Peng, Bi-Hung; Lee J Ching; Campbell Gerald A (December 2003). "In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis". J. Biol. Chem. 278 (49): 49644–49651. doi:10.1074/jbc.M302782200. ISSN 0021-9258. PMID 14512431.49644-49651&rft.date=2003-12&rft.issn=0021-9258&rft_id=info:pmid/14512431&rft_id=info:doi/10.1074/jbc.M302782200&rft.aulast=Peng&rft.aufirst=Bi-Hung&rft.au=Lee J Ching&rft.au=Campbell Gerald A&rft_id=https://doi.org/10.1074%2Fjbc.M302782200&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  12. ^ Kazmierczak M, Harris SL, Kazmierczak P, Shah P, Starovoytov V, Ohlemiller KK, Schwander M (November 2015). "Progressive Hearing Loss in Mice Carrying a Mutation in Usp53". The Journal of Neuroscience. 35 (47): 15582–98. doi:10.1523/JNEUROSCI.1965-15.2015. PMC 4659823. PMID 26609154.15582-98&rft.date=2015-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659823#id-name=PMC&rft_id=info:pmid/26609154&rft_id=info:doi/10.1523/JNEUROSCI.1965-15.2015&rft.aulast=Kazmierczak&rft.aufirst=M&rft.au=Harris, SL&rft.au=Kazmierczak, P&rft.au=Shah, P&rft.au=Starovoytov, V&rft.au=Ohlemiller, KK&rft.au=Schwander, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659823&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">

Further reading

[edit]
  • Denker BM, Nigam SK (1998). "Molecular structure and assembly of the tight junction". Am. J. Physiol. 274 (1 Pt 2): F1–9. doi:10.1152/ajprenal.1998.274.1.F1. PMID 9458817.
  • González-Mariscal L, Betanzos A, Avila-Flores A (2000). "MAGUK proteins: structure and role in the tight junction". Semin. Cell Dev. Biol. 11 (4): 315–324. doi:10.1006/scdb.2000.0178. PMID 10966866.315-324&rft.date=2000&rft_id=info:doi/10.1006/scdb.2000.0178&rft_id=info:pmid/10966866&rft.aulast=González-Mariscal&rft.aufirst=L&rft.au=Betanzos, A&rft.au=Avila-Flores, A&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–1357. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.1347-1357&rft.date=2006&rft_id=info:doi/10.1016/j.micinf.2005.11.014&rft_id=info:pmid/16697675&rft.aulast=King&rft.aufirst=JE&rft.au=Eugenin, EA&rft.au=Buckner, CM&rft.au=Berman, JW&rft_id=https://doi.org/10.1016%2Fj.micinf.2005.11.014&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Van Itallie CM, Balda MS, Anderson JM (1995). "Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells". J. Cell Sci. 108 (4): 1735–42. doi:10.1242/jcs.108.4.1735. PMID 7542259.1735-42&rft.date=1995&rft_id=info:doi/10.1242/jcs.108.4.1735&rft_id=info:pmid/7542259&rft.aulast=Van Itallie&rft.aufirst=CM&rft.au=Balda, MS&rft.au=Anderson, JM&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Beatch M, Jesaitis LA, Gallin WJ, et al. (1996). "The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region". J. Biol. Chem. 271 (42): 25723–25726. doi:10.1074/jbc.271.42.25723. PMID 8824195.25723-25726&rft.date=1996&rft_id=info:doi/10.1074/jbc.271.42.25723&rft_id=info:pmid/8824195&rft.au=Beatch M&rft.au=Jesaitis LA&rft.au=Gallin WJ&rft.au=Goodenough, DA&rft.au=Stevenson, BR&rft_id=https://doi.org/10.1074%2Fjbc.271.42.25723&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. PMID 10026224.5981-5986&rft.date=1999&rft_id=info:doi/10.1074/jbc.274.9.5981&rft_id=info:pmid/10026224&rft.aulast=Itoh&rft.aufirst=M&rft.au=Morita, K&rft.au=Tsukita, S&rft_id=https://doi.org/10.1074%2Fjbc.274.9.5981&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Chlenski A, Ketels KV, Tsao MS, et al. (1999). "Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma". Int. J. Cancer. 82 (1): 137–144. doi:10.1002/(SICI)1097-0215(19990702)82:1<137::AID-IJC23>3.0.CO;2-F. PMID 10360833. S2CID 11349543.137-144&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:11349543#id-name=S2CID&rft_id=info:pmid/10360833&rft_id=info:doi/10.1002/(SICI)1097-0215(19990702)82:1<137::AID-IJC23>3.0.CO;2-F&rft.au=Chlenski A&rft.au=Ketels KV&rft.au=Tsao MS&rft.au=Talamonti, Mark S.&rft.au=Anderson, Marla R.&rft.au=Oyasu, Ryoichi&rft.au=Scarpelli, Dante G.&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Chlenski A, Ketels KV, Engeriser JL, et al. (1999). "zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells". Int. J. Cancer. 83 (3): 349–358. doi:10.1002/(SICI)1097-0215(19991029)83:3<349::AID-IJC10>3.0.CO;2-C. PMID 10495427.349-358&rft.date=1999&rft_id=info:doi/10.1002/(SICI)1097-0215(19991029)83:3<349::AID-IJC10>3.0.CO;2-C&rft_id=info:pmid/10495427&rft.au=Chlenski A&rft.au=Ketels KV&rft.au=Engeriser JL&rft.au=Talamonti, Mark S.&rft.au=Tsao, Ming-Sound&rft.au=Koutnikova, Hanna&rft.au=Oyasu, Ryoichi&rft.au=Scarpelli, Dante G.&rft_id=https://doi.org/10.1002%2F%28SICI%291097-0215%2819991029%2983%3A3%3C349%3A%3AAID-IJC10%3E3.0.CO%3B2-C&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. PMID 10575001.35179-35185&rft.date=2000&rft_id=info:doi/10.1074/jbc.274.49.35179&rft_id=info:pmid/10575001&rft.aulast=Wittchen&rft.aufirst=ES&rft.au=Haskins, J&rft.au=Stevenson, BR&rft_id=https://doi.org/10.1074%2Fjbc.274.49.35179&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–1363. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.1351-1363&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168087#id-name=PMC&rft_id=info:pmid/10601346&rft_id=info:doi/10.1083/jcb.147.6.1351&rft.au=Itoh M&rft.au=Furuse M&rft.au=Morita K&rft.au=Kubota, K&rft.au=Saitou, M&rft.au=Tsukita, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168087&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Cordenonsi M, D'Atri F, Hammar E, et al. (2000). "Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin". J. Cell Biol. 147 (7): 1569–1582. doi:10.1083/jcb.147.7.1569. PMC 2174252. PMID 10613913.1569-1582&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174252#id-name=PMC&rft_id=info:pmid/10613913&rft_id=info:doi/10.1083/jcb.147.7.1569&rft.au=Cordenonsi M&rft.au=D'Atri F&rft.au=Hammar E&rft.au=Parry, DA&rft.au=Kendrick-Jones, J&rft.au=Shore, D&rft.au=Citi, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174252&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ (2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. PMID 10874042.30573-30585&rft.date=2000&rft_id=info:doi/10.1074/jbc.M004578200&rft_id=info:pmid/10874042&rft.aulast=Mattagajasingh&rft.aufirst=SN&rft.au=Huang, SC&rft.au=Hartenstein, JS&rft.au=Benz, EJ&rft_id=https://doi.org/10.1074%2Fjbc.M004578200&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Chlenski A, Ketels KV, Korovaitseva GI, et al. (2000). "Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues". Biochim. Biophys. Acta. 1493 (3): 319–24. doi:10.1016/S0167-4781(00)00185-8. PMID 11018256.319-24&rft.date=2000&rft_id=info:doi/10.1016/S0167-4781(00)00185-8&rft_id=info:pmid/11018256&rft.au=Chlenski A&rft.au=Ketels KV&rft.au=Korovaitseva GI&rft.au=Talamonti, MS&rft.au=Oyasu, R&rft.au=Scarpelli, DG&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Citi S, D'Atri F, Parry DA (2000). "Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly". J. Struct. Biol. 131 (2): 135–145. doi:10.1006/jsbi.2000.4284. PMID 11042084.135-145&rft.date=2000&rft_id=info:doi/10.1006/jsbi.2000.4284&rft_id=info:pmid/11042084&rft.aulast=Citi&rft.aufirst=S&rft.au=D'Atri, F&rft.au=Parry, DA&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.1788-1795&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948#id-name=PMC&rft_id=info:pmid/11076863&rft_id=info:doi/10.1101/gr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple, GF&rft.au=Brasch, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Glaunsinger BA, Weiss RS, Lee SS, Javier R (2001). "Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2". EMBO J. 20 (20): 5578–5586. doi:10.1093/emboj/20.20.5578. PMC 125668. PMID 11598001.5578-5586&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125668#id-name=PMC&rft_id=info:pmid/11598001&rft_id=info:doi/10.1093/emboj/20.20.5578&rft.aulast=Glaunsinger&rft.aufirst=BA&rft.au=Weiss, RS&rft.au=Lee, SS&rft.au=Javier, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125668&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
  • Islas S, Vega J, Ponce L, González-Mariscal L (2002). "Nuclear localization of the tight junction protein ZO-2 in epithelial cells". Exp. Cell Res. 274 (1): 138–148. doi:10.1006/excr.2001.5457. PMID 11855865.138-148&rft.date=2002&rft_id=info:doi/10.1006/excr.2001.5457&rft_id=info:pmid/11855865&rft.aulast=Islas&rft.aufirst=S&rft.au=Vega, J&rft.au=Ponce, L&rft.au=González-Mariscal, L&rfr_id=info:sid/en.wikipedia.org:Tight junction protein ZO-2" class="Z3988">
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