Jump to content

SLC26A6

From Wikipedia, the free encyclopedia
SLC26A6
Identifiers
AliasesSLC26A6, solute carrier family 26 member 6
External IDsOMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_134420

RefSeq (protein)

NP_599252
NP_001395316

Location (UCSC)Chr 3: 48.63 – 48.64 MbChr 9: 108.73 – 108.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]

Associated diseases

[edit]

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.[9]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000225697Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023259Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
  6. ^ Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
  7. ^ a b "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
  8. ^ Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.
  9. ^ "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.