Ro10-5824

Ro10-5824
Identifiers
	IUPAC name 2-methyl-5-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]pyrimidin-4-amine;
CAS Number	189744-46-5 ;
PubChem CID	16759175;
ChemSpider	14016802;
UNII	8X35VUU4YY;
ChEMBL	ChEMBL1616116;
CompTox Dashboard (EPA)	DTXSID501029525 ;
Chemical and physical data
Formula	C17H20N4
Molar mass	280.375 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3ccccc3C(=CC2)CCN2Cc1cnc(C)nc1N;
	InChI InChI=1S/C17H20N4/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20); Key:KABDATZAOUSYES-UHFFFAOYSA-N;
	(verify)

Ro10-5824 is a drug which acts as a dopamine receptor partial agonist selective for the D₄ subtype, and has nootropic effects in animal studies.^[1]^[2]

References

^ Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). "RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice". Neuropharmacology. 44 (4): 473–81. doi:10.1016/S0028-3908(02)00412-4. PMID 12646284. S2CID 16863644.
^ Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). "Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K channel modulation in transfected cells". The International Journal of Neuropsychopharmacology. 11 (3): 293–307. doi:10.1017/S1461145707008061. PMID 17897483.

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