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RREB1

From Wikipedia, the free encyclopedia

RREB1
Identifiers
AliasesRREB1, FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDsOMIM: 602209; MGI: 2443664; HomoloGene: 2218; GeneCards: RREB1; OMA:RREB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003698
NM_001003699
NM_001003700
NM_001168344
NM_002955

NM_001013392
NM_001039188
NM_001177868
NM_001177869
NM_026830

RefSeq (protein)
Location (UCSC)Chr 6: 7.11 – 7.25 MbChr 13: 37.96 – 38.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.[5][6][7]

Clinical significance

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Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124782Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039087Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi:10.1006/geno.1997.5001. PMID 9367691.
  6. ^ Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. Bibcode:2008CBio...18..532M. doi:10.1016/j.cub.2008.03.024. PMID 18394891. S2CID 17251337.
  7. ^ "Entrez Gene: RREB1 ras responsive element binding protein 1".
  8. ^ Bonomo JA, Guan M, Ng MC, Palmer ND, Hicks PJ, Keaton JM, Lea JP, Langefeld CD, Freedman BI, Bowden DW (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197. PMID 25027322.

Further reading

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