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PPP1CB

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PPP1CB
Identifiers
AliasesPPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta, NSLH2, PPP1beta, PP1c, MP
External IDsOMIM: 600590; MGI: 104871; HomoloGene: 37659; GeneCards: PPP1CB; OMA:PPP1CB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_206877
NM_002709
NM_206876

NM_172707

RefSeq (protein)

NP_002700
NP_996759

NP_766295

Location (UCSC)Chr 2: 28.75 – 28.8 MbChr 5: 32.62 – 32.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.[5]

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]

Interactions

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PPP1CB has been shown to interact with PPP1R15A,[7][8] Nucleolin,[9] SMARCB1[7] and PPP1R9B.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213639Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014956Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT (March 1994). "Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB)". Biochim Biophys Acta. 1220 (2): 212–8. doi:10.1016/0167-4889(94)90138-4. PMID 8312365.212-8&rft.date=1994-03&rft_id=info:doi/10.1016/0167-4889(94)90138-4&rft_id=info:pmid/8312365&rft.aulast=Barker&rft.aufirst=HM&rft.au=Brewis, ND&rft.au=Street, AJ&rft.au=Spurr, NK&rft.au=Cohen, PT&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
  6. ^ "Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform".
  7. ^ a b Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.27706-15&rft.date=2002-08&rft.issn=0021-9258&rft_id=info:pmid/12016208&rft_id=info:doi/10.1074/jbc.M200955200&rft.aulast=Wu&rft.aufirst=Daniel Y&rft.au=Tkachuck Douglas C&rft.au=Roberson Rachel S&rft.au=Schubach William H&rft_id=https://doi.org/10.1074%2Fjbc.M200955200&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
  8. ^ Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.6841-50&rft.date=2001-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99861#id-name=PMC&rft.issn=0270-7306&rft_id=info:pmid/11564868&rft_id=info:doi/10.1128/MCB.21.20.6841-6850.2001&rft.aulast=Connor&rft.aufirst=J H&rft.au=Weiser D C&rft.au=Li S&rft.au=Hallenbeck J M&rft.au=Shenolikar S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99861&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
  9. ^ Morimoto H, Okamura Hirohiko, Haneji Tatsuji (September 2002). "Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells". J. Histochem. Cytochem. 50 (9): 1187–93. doi:10.1177/002215540205000905. ISSN 0022-1554. PMID 12185196.1187-93&rft.date=2002-09&rft.issn=0022-1554&rft_id=info:pmid/12185196&rft_id=info:doi/10.1177/002215540205000905&rft.aulast=Morimoto&rft.aufirst=Hiroyuki&rft.au=Okamura Hirohiko&rft.au=Haneji Tatsuji&rft_id=https://doi.org/10.1177%2F002215540205000905&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
  10. ^ Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.4365-73&rft.date=1999-04&rft.issn=0006-2960&rft_id=info:pmid/10194355&rft_id=info:doi/10.1021/bi982900m&rft.aulast=Hsieh-Wilson&rft.aufirst=L C&rft.au=Allen P B&rft.au=Watanabe T&rft.au=Nairn A C&rft.au=Greengard P&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">

Further reading

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