PPP1CB
Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.[5]
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]
Interactions
[edit]PPP1CB has been shown to interact with PPP1R15A,[7][8] Nucleolin,[9] SMARCB1[7] and PPP1R9B.[10]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000213639 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014956 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT (March 1994). "Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB)". Biochim Biophys Acta. 1220 (2): 212–8. doi:10.1016/0167-4889(94)90138-4. PMID 8312365.212-8&rft.date=1994-03&rft_id=info:doi/10.1016/0167-4889(94)90138-4&rft_id=info:pmid/8312365&rft.aulast=Barker&rft.aufirst=HM&rft.au=Brewis, ND&rft.au=Street, AJ&rft.au=Spurr, NK&rft.au=Cohen, PT&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- ^ "Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform".
- ^ a b Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.27706-15&rft.date=2002-08&rft.issn=0021-9258&rft_id=info:pmid/12016208&rft_id=info:doi/10.1074/jbc.M200955200&rft.aulast=Wu&rft.aufirst=Daniel Y&rft.au=Tkachuck Douglas C&rft.au=Roberson Rachel S&rft.au=Schubach William H&rft_id=https://doi.org/10.1074%2Fjbc.M200955200&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- ^ Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.6841-50&rft.date=2001-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99861#id-name=PMC&rft.issn=0270-7306&rft_id=info:pmid/11564868&rft_id=info:doi/10.1128/MCB.21.20.6841-6850.2001&rft.aulast=Connor&rft.aufirst=J H&rft.au=Weiser D C&rft.au=Li S&rft.au=Hallenbeck J M&rft.au=Shenolikar S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99861&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- ^ Morimoto H, Okamura Hirohiko, Haneji Tatsuji (September 2002). "Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells". J. Histochem. Cytochem. 50 (9): 1187–93. doi:10.1177/002215540205000905. ISSN 0022-1554. PMID 12185196.1187-93&rft.date=2002-09&rft.issn=0022-1554&rft_id=info:pmid/12185196&rft_id=info:doi/10.1177/002215540205000905&rft.aulast=Morimoto&rft.aufirst=Hiroyuki&rft.au=Okamura Hirohiko&rft.au=Haneji Tatsuji&rft_id=https://doi.org/10.1177%2F002215540205000905&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- ^ Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.4365-73&rft.date=1999-04&rft.issn=0006-2960&rft_id=info:pmid/10194355&rft_id=info:doi/10.1021/bi982900m&rft.aulast=Hsieh-Wilson&rft.aufirst=L C&rft.au=Allen P B&rft.au=Watanabe T&rft.au=Nairn A C&rft.au=Greengard P&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
Further reading
[edit]- Prochazka M, Mochizuki H, Baier LJ, et al. (1995). "Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians". Diabetologia. 38 (4): 461–6. doi:10.1007/BF00410284. PMID 7796987.461-6&rft.date=1995&rft_id=info:doi/10.1007/BF00410284&rft_id=info:pmid/7796987&rft.aulast=Prochazka&rft.aufirst=M&rft.au=Mochizuki, H&rft.au=Baier, LJ&rft_id=https://doi.org/10.1007%2FBF00410284&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Saadat M, Kakinoki Y, Mizuno Y, et al. (1995). "Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization". Jpn. J. Genet. 69 (6): 697–700. doi:10.1266/jjg.69.697. PMID 7857673.697-700&rft.date=1995&rft_id=info:doi/10.1266/jjg.69.697&rft_id=info:pmid/7857673&rft.aulast=Saadat&rft.aufirst=M&rft.au=Kakinoki, Y&rft.au=Mizuno, Y&rft_id=https://doi.org/10.1266%2Fjjg.69.697&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.791-806&rft.date=1997&rft_id=info:doi/10.1101/gr.6.9.791&rft_id=info:pmid/8889548&rft.aulast=Bonaldo&rft.aufirst=MF&rft.au=Lennon, G&rft.au=Soares, MB&rft_id=https://doi.org/10.1101%2Fgr.6.9.791&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.454-8&rft.date=1997&rft_id=info:doi/10.1038/385454a0&rft_id=https://api.semanticscholar.org/CorpusID:608633#id-name=S2CID&rft_id=info:pmid/9009195&rft_id=info:bibcode/1997Natur.385..454K&rft.aulast=Kawabe&rft.aufirst=T&rft.au=Muslin, AJ&rft.au=Korsmeyer, SJ&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Fujioka M, Takahashi N, Odai H, et al. (1998). "A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping". Genomics. 49 (1): 59–68. doi:10.1006/geno.1998.5222. PMID 9570949.59-68&rft.date=1998&rft_id=info:doi/10.1006/geno.1998.5222&rft_id=info:pmid/9570949&rft.aulast=Fujioka&rft.aufirst=M&rft.au=Takahashi, N&rft.au=Odai, H&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Verin AD, Csortos C, Durbin SD, et al. (2000). "Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses". J. Cell. Biochem. 79 (1): 113–25. doi:10.1002/1097-4644(2000)79:1<113::AID-JCB110>3.0.CO;2-9. PMID 10906760. S2CID 42857803.113-25&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:42857803#id-name=S2CID&rft_id=info:pmid/10906760&rft_id=info:doi/10.1002/1097-4644(2000)79:1<113::AID-JCB110>3.0.CO;2-9&rft.aulast=Verin&rft.aufirst=AD&rft.au=Csortos, C&rft.au=Durbin, SD&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.1788-95&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948#id-name=PMC&rft_id=info:pmid/11076863&rft_id=info:doi/10.1101/gr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple, GF&rft.au=Brasch, MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.422-35&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072#id-name=PMC&rft_id=info:pmid/11230166&rft_id=info:doi/10.1101/gr.GR1547R&rft.aulast=Wiemann&rft.aufirst=S&rft.au=Weil, B&rft.au=Wellenreuther, R&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Tan I, Ng CH, Lim L, Leung T (2001). "Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton". J. Biol. Chem. 276 (24): 21209–16. doi:10.1074/jbc.M102615200. PMID 11399775.21209-16&rft.date=2001&rft_id=info:doi/10.1074/jbc.M102615200&rft_id=info:pmid/11399775&rft.aulast=Tan&rft.aufirst=I&rft.au=Ng, CH&rft.au=Lim, L&rft.au=Leung, T&rft_id=https://doi.org/10.1074%2Fjbc.M102615200&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E (2001). "Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase". Biochem. J. 358 (Pt 2): 407–14. doi:10.1042/0264-6021:3580407. PMC 1222073. PMID 11513739.407-14&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222073#id-name=PMC&rft_id=info:pmid/11513739&rft_id=info:doi/10.1042/0264-6021:3580407&rft.aulast=Fresu&rft.aufirst=M&rft.au=Bianchi, M&rft.au=Parsons, JT&rft.au=Villa-Moruzzi, E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222073&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.1-11&rft.date=2002&rft_id=info:doi/10.1016/S0960-9822(01)00650-9&rft_id=https://api.semanticscholar.org/CorpusID:14132033#id-name=S2CID&rft_id=info:pmid/11790298&rft_id=info:bibcode/2002CBio...12....1A&rft.aulast=Andersen&rft.aufirst=JS&rft.au=Lyon, CE&rft.au=Fox, AH&rft_id=https://doi.org/10.1016%2FS0960-9822%2801%2900650-9&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat". Virology. 296 (1): 6–16. doi:10.1006/viro.2002.1438. PMID 12036313.6-16&rft.date=2002&rft_id=info:doi/10.1006/viro.2002.1438&rft_id=info:pmid/12036313&rft.aulast=Bharucha&rft.aufirst=DC&rft.au=Zhou, M&rft.au=Nekhai, S&rft_id=https://doi.org/10.1006%2Fviro.2002.1438&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.47331-7&rft.date=2003&rft_id=info:doi/10.1074/jbc.M206838200&rft_id=info:pmid/12226088&rft.aulast=Ceulemans&rft.aufirst=H&rft.au=Vulsteke, V&rft.au=De Maeyer, M&rft_id=https://doi.org/10.1074%2Fjbc.M206838200&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.566-9&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:23783563#id-name=S2CID&rft_id=info:pmid/12665801&rft_id=info:doi/10.1038/nbt810&rft.aulast=Gevaert&rft.aufirst=K&rft.au=Goethals, M&rft.au=Martens, L&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.358-71&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:22016092#id-name=S2CID&rft_id=info:pmid/12775419&rft_id=info:doi/10.1080/13550280390201119&rft.aulast=Galey&rft.aufirst=D&rft.au=Becker, K&rft.au=Haughey, N&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Ammosova T, Jerebtsova M, Beullens M, et al. (2003). "Nuclear protein phosphatase-1 regulates HIV-1 transcription". J. Biol. Chem. 278 (34): 32189–94. doi:10.1074/jbc.M300521200. PMID 12788939.32189-94&rft.date=2003&rft_id=info:doi/10.1074/jbc.M300521200&rft_id=info:pmid/12788939&rft.aulast=Ammosova&rft.aufirst=T&rft.au=Jerebtsova, M&rft.au=Beullens, M&rft_id=https://doi.org/10.1074%2Fjbc.M300521200&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Llorian M, Beullens M, Andrés I, et al. (2004). "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1". Biochem. J. 378 (Pt 1): 229–38. doi:10.1042/BJ20030950. PMC 1223944. PMID 14640981.229-38&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223944#id-name=PMC&rft_id=info:pmid/14640981&rft_id=info:doi/10.1042/BJ20030950&rft.aulast=Llorian&rft.aufirst=M&rft.au=Beullens, M&rft.au=Andrés, I&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223944&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.97-105&rft.date=2004&rft_id=https://api.semanticscholar.org/CorpusID:11683986#id-name=S2CID&rft_id=info:pmid/14743216&rft_id=info:doi/10.1038/ncb1086&rft.aulast=Bouwmeester&rft.aufirst=T&rft.au=Bauch, A&rft.au=Ruffner, H&rfr_id=info:sid/en.wikipedia.org:PPP1CB" class="Z3988">