PDE1C

PDE1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LXS
Identifiers
Aliases	PDE1C, Hcam3, cam-PDE 1C, hCam-3, phosphodiesterase 1C, DFNA74
External IDs	OMIM: 602987; MGI: 108413; HomoloGene: 3682; GeneCards: PDE1C; OMA:PDE1C - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	32,428,131 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	56,629,472 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; right ventricle; ; corpus callosum; ; apex of heart; ; left ventricle; ; sural nerve; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; internal globus pallidus; ; right auricle;
	Top expressed in
	lumbar spinal ganglion; ; spermatocyte; ; spermatid; ; retinal pigment epithelium; ; supraoptic nucleus; ; aortic valve; ; ascending aorta; ; ciliary body; ; iris; ; olfactory epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; calmodulin binding; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytosol; soma;
Biological process	signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5137
	18575
	ENSG00000154678
	ENSMUSG00000004347
	Q14123
	Q64338
NM_001191056; NM_001191057; NM_001191058; NM_001191059; NM_005020;
	NM_001322055; NM_001322056; NM_001322057; NM_001322058; NM_001322059
NM_001025568; NM_001159952; NM_001159953; NM_001159955; NM_001159956;
	NM_001159957; NM_001159960; NM_011054; NM_001355475
NP_001177985; NP_001177986; NP_001177987; NP_001177988; NP_001308984;
	NP_001308985; NP_001308986; NP_001308987; NP_001308988; NP_005011
NP_001020739; NP_001153424; NP_001153425; NP_001153427; NP_001153428;
	NP_001153429; NP_001153432; NP_035184; NP_001342404
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154678 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004347 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.
^ "Entrez Gene: PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa".

Vandeput F, Wolda SL, Krall J, et al. (2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes". J. Biol. Chem. 282 (45): 32749–57. doi:10.1074/jbc.M703173200. PMID 17726023.
Dolci S, Belmonte A, Santone R, et al. (2006). "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases". Biochem. Biophys. Res. Commun. 341 (3): 837–46. doi:10.1016/j.bbrc.2006.01.035. hdl:11573/979485. PMID 16455054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE (2002). "Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation". Circ. Res. 90 (2): 151–7. doi:10.1161/hh0202.104108. PMID 11834707.
Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154678 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004347 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8557689-5] Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.

[entrez-6] "Entrez Gene: PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa".

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References

Further reading