Solute carrier organic anion transporter family member 4c1

SLCO4C1
Identifiers
Aliases	SLCO4C1, OATP-H, OATP-M1, OATP4C1, OATPX, PRO2176, SLC21A20, solute carrier organic anion transporter family member 4C1
External IDs	OMIM: 609013; MGI: 2442784; HomoloGene: 62654; GeneCards: SLCO4C1; OMA:SLCO4C1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	102,296,284 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	96,799,896 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; palpebral conjunctiva; ; renal medulla; ; lower lobe of lung; ; glomerulus; ; mucosa of paranasal sinus; ; metanephric glomerulus; ; human kidney; ; bronchial epithelial cell; ; bone marrow;
	Top expressed in
	seminal vesicula; ; left lung lobe; ; granulocyte; ; prostate; ; lobe of prostate; ; nasal epithelium; ; olfactory epithelium; ; lacrimal gland; ; yolk sac; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; sodium-independent organic anion transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; extracellular exosome; membrane; azurophil granule membrane; specific granule membrane; integral component of plasma membrane;
Biological process	multicellular organism development; cell differentiation; ion transport; spermatogenesis; neutrophil degranulation; sodium-independent organic anion transport; transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	353189
	227394
	ENSG00000173930
	ENSMUSG00000040693
	Q6ZQN7
	Q8BGD4
	NM_180991
	NM_172658
	NP_851322
	NP_766246
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.^[5]^[6]

Function

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173930 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040693 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mikkaichi T, Suzuki T, Onogawa T, et al. (March 2004). "Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3569–74. Bibcode:2004PNAS..101.3569M. doi:10.1073/pnas.0304987101. PMC 373503. PMID 14993604.
^ "Entrez Gene: Solute carrier organic anion transporter family member 4C1". Retrieved 2016-03-11.

Function

References

Further reading