Mervyn Bibb
Mervyn Bibb | |
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| Alma mater | University of East Anglia |
| Awards | FRS (2013)[1] |
| Scientific career | |
| Fields | |
| Institutions | |
| Thesis | Genetic and physical studies of a Streptomyces coelicolor plasmid (1978) |
| Doctoral advisor | David Hopwood[5][6][4] |
| Website | |
Mervyn James Bibb FRS is an Emeritus Fellow at the John Innes Centre, Norwich, UK.[7]
Education
[edit]Bibb was educated at the University of East Anglia where he graduated with a BSc in Biological Sciences and was awarded a PhD in 1978 for studies of plasmids in Streptomyces coelicolor.[8]
Research
[edit]Bibb's research[9][10] focused on
- The regulation of secondary metabolism (antibiotic production) in streptomycetes[11]
- Functional genomics in Streptomyces, particularly transcriptome and proteome analysis
- Lantibiotics from actinomycetes
Awards and honours
[edit]Bibb was elected a Fellow of the Royal Society in 2013. His nomination reads:
Mervyn Bibb is nominated for his seminal contributions to the genetic manipulation of antibiotic-producing bacteria, and to our understanding of antibiotic production and its regulation. He characterised Streptomyces plasmids, invented a method for introducing them into Streptomyces, and then developed cloning systems. This opened the way to his characterisation of the basic features of Streptomyces genes. He then applied this knowledge to the synthesis of antibiotics and their global and pathway-specific regulation. New therapeutic agents and ground-breaking approaches to yield improvement are emerging from this work.[1]
References
[edit]- ^ a b http://royalsociety.org/people/mervyn-bibb/ [dead link]
- ^ Mervyn Bibb publications indexed by Google Scholar
- ^ Bibb, M; Schottel, J. L.; Cohen, S. N. (1980). "A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces". Nature. 284 (5756): 526–31. Bibcode:1980Natur.284..526B. doi:10.1038/284526a0. PMID 7366721. S2CID 25606114.
- ^ a b Q&A with Professor Mervyn Bibb
- ^ Bibb, M. J.; Ward, J. M.; Hopwood, D. A. (1978). "Transformation of plasmid DNA into Streptomyces at high frequency". Nature. 274 (5669): 398–400. Bibcode:1978Natur.274..398B. doi:10.1038/274398a0. PMID 672966. S2CID 4221380.
- ^ Freeman, R. F.; Bibb, M. J.; Hopwood, D. A. (1977). "Chloramphenicol acetylransferase-independent chloramphenicol resistance in Streptomyces coelicolor A3(2)". Journal of General Microbiology. 98 (2): 453–65. doi:10.1099/00221287-98-2-453. PMID 856941.
- ^ Mervyn Bibb's publications indexed by the Scopus bibliographic database. (subscription required)
- ^ Bibb, Mervyn (1978). Genetic and physical studies of a Streptomyces coelicolor plasmid (PhD thesis). University of East Anglia.
- ^ Bibb, M. J.; Findlay, P. R.; Johnson, M. W. (1984). "The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences". Gene. 30 (1–3): 157–66. doi:10.1016/0378-1119(84)90116-1. PMID 6096212.
- ^ Ward, J. M.; Janssen, G. R.; Kieser, T.; Bibb, M. J.; Buttner, M. J.; Bibb, M. J. (1986). "Construction and characterisation of a series of multi-copy promoter-probe plasmid vectors for Streptomyces using the aminoglycoside phosphotransferase gene from Tn5 as indicator". MGG Molecular & General Genetics. 203 (3): 468–478. doi:10.1007/BF00422072. PMID 3018431. S2CID 28633568.
- ^ Bibb, M. J. (2005). "Regulation of secondary metabolism in streptomycetes". Current Opinion in Microbiology. 8 (2): 208–15. doi:10.1016/j.mib.2005.02.016. PMID 15802254.
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