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Matthias Lütolf

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Professor
Matthias Lütolf
Born1973 (age 50–51)
CitizenshipSwiss
EducationMaterials engineering
Biomedical engineering
Alma materETH Zurich
Stanford University
Known forBiomaterials
stem cell biology
Organoid models
Scientific career
FieldsStem Cells
Biomaterials
Tissue Engineering
Microfluidics
Single-Cell Analysis
High-Throughput Screening
InstitutionsEPFL (École Polytechnique Fédérale de Lausanne)
ThesisCell-responsive synthetic hydrogels (2002)
Doctoral advisorJeffrey Hubbell
Websitewww.epfl.ch/labs/lutolf-lab/

Matthias Lutolf (born in 1973, also known as Matthias Lütolf) is a bio-engineer and a professor at EPFL (École Polytechnique Fédérale de Lausanne) where he leads the Laboratory of Stem Cell Bioengineering.[1][2] He is specialised in biomaterials, and in combining stem cell biology and engineering to develop improved organoid models.[3][4] In 2021, he became the scientific director for Roche's Institute for Translation Bioengineering in Basel.[5]

Career

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Lutolf studied materials engineering at ETH Zurich where he graduated in 1998. In 2002, he received his PhD in biomedical engineering from ETH Zurich for his studies on cell-responsive hydrogels for tissue engineering and cell culture, in the group of Jeffrey Hubbell.[6][7] He completed postdoctoral studies in the laboratory of Helen Blau at Stanford University, where he worked on novel cell culture approaches for blood and muscle stem cells, so called synthetic niches.[8][9] In 2007, he founded his own laboratory at EPFL, where he was promoted to associate professor in 2014 and full professor in 2018.[1] From 2014 to 2018, he was director of EPFL's Institute of Bioengineering.[10] In June 2021, Lutolf became scientific director of the newly established Roche Institute for Translational Bioengineering in Basel, Switzerland.[5]

Research

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Lutolf's laboratory develops in vitro organoids mimicking healthy and diseased tissues and organs.[2] Specifically, Lutolf uses bioengineering strategies to guide stem cell-based development to build novel organoids with improved reproducibility and physiological relevance for basic science and in vitro testing of drug candidates. His team has developed approaches to generate organoids in fully controllable 3D matrices,[11][12] and has contributed to the understanding of how extrinsic biochemical and physical factors control stem cell fate and organogenesis.[13][14] His team has developed concepts based on microfabrication,[15] bioprinting,[16] and microfluidics[17] to improve the reproducibility, size, shape, and function of organoids.

Distinctions

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In 2007, Lutolf received the European Young Investigator (EURYI) Award by the European Science Foundation.[18] Since 2018, he is elected as member of the European Molecular Biology Organization (EMBO).[19] He serves as associate editor of The Company of Biologists' journal Development.[20]

Publications

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References

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  1. ^ a b "13 new professors appointed at ETH Zurich and EPFL | ETH-Board". www.ethrat.ch. Retrieved 2021-08-20.
  2. ^ a b "Laboratory of Stem Cell Bioengineering ‐ EPFL". www.epfl.ch. Retrieved 2021-08-20.
  3. ^ "Institute of Chemical Sciences and Engineering – ISIC". www.epfl.ch. Retrieved 2020-08-24.
  4. ^ "Laboratory of Stem Cell Bioengineering ‐ EPFL". www.epfl.ch. Retrieved 2020-08-24.
  5. ^ a b "The Roche Institute for Translational Bioengineering". www.roche.com. Retrieved 2021-08-20.
  6. ^ Lütolf, Matthias (2002). Cell-responsive synthetic hydrogels (Doctoral Thesis thesis). ETH Zurich.
  7. ^ Lutolf, Matthias P.; Weber, Franz E.; Schmoekel, Hugo G.; Schense, Jason C.; Kohler, Thomas; Müller, Ralph; Hubbell, Jeffrey A. (May 2003). "Repair of bone defects using synthetic mimetics of collagenous extracellular matrices". Nature Biotechnology. 21 (5): 513–518. doi:10.1038/nbt818. ISSN 1087-0156. PMID 12704396. S2CID 7144863.
  8. ^ Lutolf, Matthias P.; Gilbert, Penney M.; Blau, Helen M. (November 2009). "Designing materials to direct stem-cell fate". Nature. 462 (7272): 433–441. Bibcode:2009Natur.462..433L. doi:10.1038/nature08602. ISSN 1476-4687. PMC 2908011. PMID 19940913.
  9. ^ Gilbert, P. M.; Havenstrite, K. L.; Magnusson, K. E. G.; Sacco, A.; Leonardi, N. A.; Kraft, P.; Nguyen, N. K.; Thrun, S.; Lutolf, M. P.; Blau, H. M. (2010-08-27). "Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture". Science. 329 (5995): 1078–1081. Bibcode:2010Sci...329.1078G. doi:10.1126/science.1191035. ISSN 0036-8075. PMC 2929271. PMID 20647425.
  10. ^ Bhagwat, V. M.; Ramachandran, B. V. (1975-09-15). "Malathion A and B esterases of mouse liver-I". Biochemical Pharmacology. 24 (18): 1713–1717. doi:10.1016/0006-2952(75)90011-8. ISSN 0006-2952. PMID 14.
  11. ^ Gjorevski, Nikolce; Sachs, Norman; Manfrin, Andrea; Giger, Sonja; Bragina, Maiia E.; Ordóñez-Morán, Paloma; Clevers, Hans; Lutolf, Matthias P. (November 2016). "Designer matrices for intestinal stem cell and organoid culture". Nature. 539 (7630): 560–564. doi:10.1038/nature20168. ISSN 1476-4687. PMID 27851739. S2CID 4470849.
  12. ^ Caiazzo, Massimiliano; Okawa, Yuya; Ranga, Adrian; Piersigilli, Alessandra; Tabata, Yoji; Lutolf, Matthias P. (March 2016). "Defined three-dimensional microenvironments boost induction of pluripotency". Nature Materials. 15 (3): 344–352. Bibcode:2016NatMa..15..344C. doi:10.1038/nmat4536. ISSN 1476-4660. PMID 26752655.
  13. ^ Gobaa, Samy; Hoehnel, Sylke; Roccio, Marta; Negro, Andrea; Kobel, Stefan; Lutolf, Matthias P. (November 2011). "Artificial niche microarrays for probing single stem cell fate in high throughput". Nature Methods. 8 (11): 949–955. doi:10.1038/nmeth.1732. ISSN 1548-7105. PMID 21983923. S2CID 310516.
  14. ^ Ranga, A.; Gobaa, S.; Okawa, Y.; Mosiewicz, K.; Negro, A.; Lutolf, M. P. (2014-07-14). "3D niche microarrays for systems-level analyses of cell fate". Nature Communications. 5 (1): 4324. Bibcode:2014NatCo...5.4324R. doi:10.1038/ncomms5324. ISSN 2041-1723. PMC 4104440. PMID 25027775.
  15. ^ Brandenberg, Nathalie; Hoehnel, Sylke; Kuttler, Fabien; Homicsko, Krisztian; Ceroni, Camilla; Ringel, Till; Gjorevski, Nikolce; Schwank, Gerald; Coukos, George; Turcatti, Gerardo; Lutolf, Matthias P. (September 2020). "High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays". Nature Biomedical Engineering. 4 (9): 863–874. doi:10.1038/s41551-020-0565-2. ISSN 2157-846X. PMID 32514094. S2CID 219543643.
  16. ^ Brassard, Jonathan A.; Nikolaev, Mike; Hübscher, Tania; Hofer, Moritz; Lutolf, Matthias P. (January 2021). "Recapitulating macro-scale tissue self-organization through organoid bioprinting". Nature Materials. 20 (1): 22–29. Bibcode:2021NatMa..20...22B. doi:10.1038/s41563-020-00803-5. ISSN 1476-4660. PMID 32958879. S2CID 221825383.
  17. ^ Nikolaev, Mikhail; Mitrofanova, Olga; Broguiere, Nicolas; Geraldo, Sara; Dutta, Devanjali; Tabata, Yoji; Elci, Bilge; Brandenberg, Nathalie; Kolotuev, Irina; Gjorevski, Nikolce; Clevers, Hans (September 2020). "Homeostatic mini-intestines through scaffold-guided organoid morphogenesis". Nature. 585 (7826): 574–578. Bibcode:2020Natur.585..574N. doi:10.1038/s41586-020-2724-8. ISSN 1476-4687. PMID 32939089. S2CID 221769498.
  18. ^ "2007 : European Science Foundation". archives.esf.org. Retrieved 2021-08-20.
  19. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2021-08-20.
  20. ^ "Editors and Board | Development | The Company of Biologists | Development | The Company of Biologists". journals.biologists.com. Retrieved 2021-08-20.
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