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MYT1L

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MYT1L
Identifiers
AliasesMYT1L, NZF1, ZC2HC4B, MRD39, ZC2H2C2, myelin transcription factor 1 like, myT1-L
External IDsOMIM: 613084; MGI: 1100511; HomoloGene: 7435; GeneCards: MYT1L; OMA:MYT1L - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 2: 1.79 – 2.33 MbChr 12: 29.53 – 29.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myelin transcription factor 1 like is a protein that in humans is encoded by the MYT1L gene. [5]

Function

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This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186487Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061911Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Myelin transcription factor 1 like". Retrieved 2018-02-05.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.