MEOX2
Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[5][6]
Function
[edit]This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6] MEOX2 has been implicated in the initiation of tumors in glioma.[7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.[8][9]
Interactions
[edit]MEOX2 has been shown to interact with PAX1[10] and PAX3.[10]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000106511 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036144 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–540. doi:10.1006/geno.1994.1663. PMID 7713505.
- ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2".
- ^ Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. (April 2022). "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease. 13 (4): 360. doi:10.1038/s41419-022-04845-2. PMC 9016080. PMID 35436995.
- ^ Armas-López L, Piña-Sánchez P, Arrieta O, de Alba EG, Ortiz-Quintero B, Santillán-Doherty P, et al. (September 2017). "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget. 8 (40): 67056–67081. doi:10.18632/oncotarget.17715. PMC 5620156. PMID 28978016.
- ^ Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer. 160: 189–205. doi:10.1016/j.ejca.2021.10.032. PMID 34844838.
- ^ a b Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
Further reading
[edit]- Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, et al. (April 1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics. 26 (3): 550–555. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
- Reardon W, McManus SP, Summers D, Winter RM (October 1993). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". American Journal of Medical Genetics. 47 (5): 633–636. doi:10.1002/ajmg.1320470510. PMID 8266988.
- Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta. 21 Suppl A: S50–S54. doi:10.1053/plac.1999.0514. PMID 10831122.
- Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.
- Gorski DH, Leal AJ (May 2003). "Inhibition of endothelial cell activation by the homeobox gene Gax". The Journal of Surgical Research. 111 (1): 91–99. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
- Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, et al. (September 2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nature Medicine. 11 (9): 959–965. doi:10.1038/nm1287. PMID 16116430. S2CID 12998034.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (July 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Chen Y, Leal AD, Patel S, Gorski DH (January 2007). "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". The Journal of Biological Chemistry. 282 (1): 507–517. doi:10.1074/jbc.M606604200. PMC 1865102. PMID 17074759.
External links
[edit]- MEOX2 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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