MAB21L2

MAB21L2
Identifiers
Aliases	MAB21L2, MCOPS14, Mab-21-like 2 (C. elegans), mab-21 like 2, MCSKS14
External IDs	OMIM: 604357; MGI: 1346022; HomoloGene: 7824; GeneCards: MAB21L2; OMA:MAB21L2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	150,584,693 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	86,455,936 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; pons; ; retinal pigment epithelium; ; dorsal motor nucleus of vagus nerve; ; synovial joint; ; superior vestibular nucleus; ; transverse colon; ; Achilles tendon; ; cecum; ; optic nerve;
	Top expressed in
	maxillary prominence; ; mandibular prominence; ; abdominal wall; ; superior cervical ganglion; ; hand; ; lens; ; medial vestibular nucleus; ; neural layer of retina; ; iris; ; embryonic cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; cytoplasm;
Biological process	eye development; multicellular organism development; camera-type eye development; nervous system development; positive regulation of cell population proliferation; embryonic body morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10586
	23937
	ENSG00000181541
	ENSMUSG00000057777
	Q9Y586
	Q8BPP1
	NM_006439
	NM_011839
	NP_006430
	NP_035969
	Wikidata
View/Edit Human	View/Edit Mouse

Mab-21-like 2 (C. elegans) is a protein that in humans is encoded by the MAB21L2 gene.^[5]

Function

This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057777 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mab-21-like 2 (C. elegans)".

Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, Malgaretti N, Consalez GG (December 1999). "Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development". Human Molecular Genetics. 8 (13): 2397–406. doi:10.1093/hmg/8.13.2397. PMID 10556287.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181541 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mab-21-like 2 (C. elegans)".

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading