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KCNJ16

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(Redirected from Kir5.1)
KCNJ16
Identifiers
AliasesKCNJ16, BIR9, KIR5.1, potassium voltage-gated channel subfamily J member 16, potassium inwardly rectifying channel subfamily J member 16, HKTD
External IDsOMIM: 605722; MGI: 1314842; HomoloGene: 23112; GeneCards: KCNJ16; OMA:KCNJ16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3773

16517

Ensembl

ENSG00000153822

ENSMUSG00000051497

UniProt

Q9NPI9

Q9Z307

RefSeq (mRNA)

NM_001252207
NM_001252208
NM_001252209
NM_001252210
NM_010604

RefSeq (protein)

NP_001239136
NP_001239137
NP_001239138
NP_001239139
NP_034734

Location (UCSC)Chr 17: 70.05 – 70.14 MbChr 11: 110.86 – 110.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the Kir5.1 protein.[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Kir5.1 is an integral membrane protein and inward-rectifier type potassium channel. Kir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.[5]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153822 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051497 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16".

Further reading

[edit]
  • Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.509-26&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:11588492#id-name=S2CID&rft_id=info:pmid/16382105&rft_id=info:doi/10.1124/pr.57.4.11&rft.aulast=Kubo&rft.aufirst=Y&rft.au=Adelman, JP&rft.au=Clapham, DE&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Pearson WL, Dourado M, Schreiber M, et al. (1999). "Expression of a functional Kir4 family inward rectifier K channel from a gene cloned from mouse liver". J. Physiol. 514 ( Pt 3) (3): 639–53. doi:10.1111/j.1469-7793.1999.639ad.x. PMC 2269105. PMID 9882736.639-53&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269105#id-name=PMC&rft_id=info:pmid/9882736&rft_id=info:doi/10.1111/j.1469-7793.1999.639ad.x&rft.aulast=Pearson&rft.aufirst=WL&rft.au=Dourado, M&rft.au=Schreiber, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269105&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Liu Y, McKenna E, Figueroa DJ, et al. (2000). "The human inward rectifier K( ) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas". Cytogenet. Cell Genet. 90 (1–2): 60–3. doi:10.1159/000015662. PMID 11060447. S2CID 26933916.1–2&rft.pages=60-3&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:26933916#id-name=S2CID&rft_id=info:pmid/11060447&rft_id=info:doi/10.1159/000015662&rft.aulast=Liu&rft.aufirst=Y&rft.au=McKenna, E&rft.au=Figueroa, DJ&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Derst C, Karschin C, Wischmeyer E, et al. (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. Bibcode:2001FEBSL.491..305D. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. S2CID 14452157.305-11&rft.date=2001&rft_id=info:doi/10.1016/S0014-5793(01)02202-5&rft_id=https://api.semanticscholar.org/CorpusID:14452157#id-name=S2CID&rft_id=info:pmid/11240146&rft_id=info:bibcode/2001FEBSL.491..305D&rft.aulast=Derst&rft.aufirst=C&rft.au=Karschin, C&rft.au=Wischmeyer, E&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Pessia M, Imbrici P, D'Adamo MC, et al. (2001). "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. 532 (Pt 2): 359–67. doi:10.1111/j.1469-7793.2001.0359f.x. PMC 2278540. PMID 11306656.359-67&rft.date=2001&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278540#id-name=PMC&rft_id=info:pmid/11306656&rft_id=info:doi/10.1111/j.1469-7793.2001.0359f.x&rft.aulast=Pessia&rft.aufirst=M&rft.au=Imbrici, P&rft.au=D'Adamo, MC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278540&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Tanemoto M, Fujita A, Higashi K, Kurachi Y (2002). "PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain". Neuron. 34 (3): 387–97. doi:10.1016/S0896-6273(02)00675-X. PMID 11988170. S2CID 15862428.387-97&rft.date=2002&rft_id=https://api.semanticscholar.org/CorpusID:15862428#id-name=S2CID&rft_id=info:pmid/11988170&rft_id=info:doi/10.1016/S0896-6273(02)00675-X&rft.aulast=Tanemoto&rft.aufirst=M&rft.au=Fujita, A&rft.au=Higashi, K&rft.au=Kurachi, Y&rft_id=https://doi.org/10.1016%2FS0896-6273%2802%2900675-X&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Konstas AA, Korbmacher C, Tucker SJ (2003). "Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels". Am. J. Physiol., Cell Physiol. 284 (4): C910–7. doi:10.1152/ajpcell.00479.2002. PMID 12456399. S2CID 2525019.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">
  • Casamassima M, D'Adamo MC, Pessia M, Tucker SJ (2003). "Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels". J. Biol. Chem. 278 (44): 43533–40. doi:10.1074/jbc.M306596200. PMID 12923169.43533-40&rft.date=2003&rft_id=info:doi/10.1074/jbc.M306596200&rft_id=info:pmid/12923169&rft.aulast=Casamassima&rft.aufirst=M&rft.au=D'Adamo, MC&rft.au=Pessia, M&rft.au=Tucker, SJ&rft_id=https://doi.org/10.1074%2Fjbc.M306596200&rfr_id=info:sid/en.wikipedia.org:KCNJ16" class="Z3988">

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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