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Kininogen 1

From Wikipedia, the free encyclopedia
KNG1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesKNG1, BDK, BK, KNG, Kininogen 1, HMWK, HAE6, HK
External IDsOMIM: 612358; MGI: 3027157; HomoloGene: 88343; GeneCards: KNG1; OMA:KNG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166451
NM_000893
NM_001102416

NM_001102409
NM_001102410
NM_201375

RefSeq (protein)

NP_000884
NP_001095886
NP_001159923

n/a

Location (UCSC)Chr 3: 186.72 – 186.74 MbChr 16: 22.8 – 22.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein[5] that in humans is encoded by the KNG1 gene.[6][7] Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin.[5]

Expression

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The KNG1 gene uses alternative splicing to generate two different proteins: high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.

Function

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HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation.[6]

Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113889Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060459Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b UniProt: P01042
  6. ^ a b "Entrez Gene: kininogen 1".
  7. ^ KNG1 GeneCard for KNG1

Further reading

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