Kidamycin

Kidamycin
Names
	Other names Rubiflavin B
Identifiers
CAS Number	11072-82-5 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1988097;
ChemSpider	4514106;
PubChem CID	5359060;
	InChI InChI=1S/C39H48N2O9/c1-11-17(2)26-15-25(42)29-18(3)12-23-31(37(29)50-26)36(46)32-30(35(23)45)21(27-14-24(40(7)8)33(43)19(4)48-27)13-22(34(32)44)28-16-39(6,41(9)10)38(47)20(5)49-28/h11-13,15,19-20,24,27-28,33,38,43-44,47H,14,16H2,1-10H3/b17-11 Key: MFTJRTUKCOVIMD-GZTJUZNOSA-N;
	SMILES C/C=C(\C)/C1=CC(=O)C2=C(O1)C3=C(C=C2C)C(=O)C4=C(C3=O)C(=C(C=C4C5CC(C(C(O5)C)O)N(C)C)C6CC(C(C(O6)C)O)(C)N(C)C);
Properties
Chemical formula	C39H48N2O9
Molar mass	688.818 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Kidamycin is an anthracycline antibiotic with anticancer activity.^[1] It was first synthesized from a strain of streptomyces bacteria isolated from a soil sample.^[2] In clinical trials, Kindamycin showed high effect against gram positive bacteria as well as multiple cancer models including Ehrlich ascites carcinoma, Sarcoma 180, NF-sarcoma, and Yoshida sarcoma.^[3]

References

^ Furukawa, M.; Hayakawa, I.; Ohta, G.; Iitaka, Y. (1 January 1971). "Structure and chemistry of kidamycin". Tetrahedron. 31 (23): 2989–2995. doi:10.1016/0040-4020(75)80324-3.2989-2995&rft.date=1971-01-01&rft_id=info:doi/10.1016/0040-4020(75)80324-3&rft.aulast=Furukawa&rft.aufirst=M.&rft.au=Hayakawa, I.&rft.au=Ohta, G.&rft.au=Iitaka, Y.&rft_id=https://linkinghub.elsevier.com/retrieve/pii/0040402075803243&rfr_id=info:sid/en.wikipedia.org:Kidamycin" class="Z3988">
^ Kanda, N. (Sep 1971). "A new antitumor antibiotic, kidamycin. I. Isolation, purification and properties of kidamycin". The Journal of Antibiotics. 24 (9): 599–606. doi:10.7164/antibiotics.24.599. PMID 5132247.599-606&rft.date=1971-09&rft_id=info:doi/10.7164/antibiotics.24.599&rft_id=info:pmid/5132247&rft.aulast=Kanda&rft.aufirst=N.&rft_id=https://doi.org/10.7164%2Fantibiotics.24.599&rfr_id=info:sid/en.wikipedia.org:Kidamycin" class="Z3988">
^ Kanda, Nobuo; Kono, Morihiro; Asano, Kazuo (1972). "A New Antitumor Antibiotic, Kidamycin". The Journal of Antibiotics. 25 (10): 553–556. doi:10.7164/antibiotics.25.553. ISSN 0021-8820. PMID 4648309.553-556&rft.date=1972&rft.issn=0021-8820&rft_id=info:pmid/4648309&rft_id=info:doi/10.7164/antibiotics.25.553&rft.aulast=Kanda&rft.aufirst=Nobuo&rft.au=Kono, Morihiro&rft.au=Asano, Kazuo&rft_id=https://www.jstage.jst.go.jp/article/antibiotics1968/25/10/25_10_553/_article&rfr_id=info:sid/en.wikipedia.org:Kidamycin" class="Z3988">

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[1] Furukawa, M.; Hayakawa, I.; Ohta, G.; Iitaka, Y. (1 January 1971). "Structure and chemistry of kidamycin". Tetrahedron. 31 (23): 2989–2995. doi:10.1016/0040-4020(75)80324-3.2989-2995&rft.date=1971-01-01&rft_id=info:doi/10.1016/0040-4020(75)80324-3&rft.aulast=Furukawa&rft.aufirst=M.&rft.au=Hayakawa, I.&rft.au=Ohta, G.&rft.au=Iitaka, Y.&rft_id=https://linkinghub.elsevier.com/retrieve/pii/0040402075803243&rfr_id=info:sid/en.wikipedia.org:Kidamycin" class="Z3988">

[2] Kanda, N. (Sep 1971). "A new antitumor antibiotic, kidamycin. I. Isolation, purification and properties of kidamycin". The Journal of Antibiotics. 24 (9): 599–606. doi:10.7164/antibiotics.24.599. PMID 5132247.599-606&rft.date=1971-09&rft_id=info:doi/10.7164/antibiotics.24.599&rft_id=info:pmid/5132247&rft.aulast=Kanda&rft.aufirst=N.&rft_id=https://doi.org/10.7164%2Fantibiotics.24.599&rfr_id=info:sid/en.wikipedia.org:Kidamycin" class="Z3988">

[3] Kanda, Nobuo; Kono, Morihiro; Asano, Kazuo (1972). "A New Antitumor Antibiotic, Kidamycin". The Journal of Antibiotics. 25 (10): 553–556. doi:10.7164/antibiotics.25.553. ISSN 0021-8820. PMID 4648309.553-556&rft.date=1972&rft.issn=0021-8820&rft_id=info:pmid/4648309&rft_id=info:doi/10.7164/antibiotics.25.553&rft.aulast=Kanda&rft.aufirst=Nobuo&rft.au=Kono, Morihiro&rft.au=Asano, Kazuo&rft_id=https://www.jstage.jst.go.jp/article/antibiotics1968/25/10/25_10_553/_article&rfr_id=info:sid/en.wikipedia.org:Kidamycin" class="Z3988">

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