INTS1

INTS1
Identifiers
Aliases	INTS1, INT1, NET28, integrator complex subunit 1, NDCAGF
External IDs	OMIM: 611345; MGI: 1915760; HomoloGene: 53111; GeneCards: INTS1; OMA:INTS1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	1,504,389 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,761,429 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; apex of heart; ; right frontal lobe; ; right hemisphere of cerebellum; ; mucosa of transverse colon; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube;
	Top expressed in
	tail of embryo; ; genital tubercle; ; spermatocyte; ; neural layer of retina; ; primary visual cortex; ; superior frontal gyrus; ; ventricular zone; ; yolk sac; ; muscle of thigh; ; spermatid;
	More reference expression data
	n/a
Orthologs
	26173
	68510
	ENSG00000164880
	ENSMUSG00000029547
	Q8N201
	Q6P4S8
	NM_001080453
	NM_026748
	NP_001073922
	NP_081024
	Wikidata
View/Edit Human	View/Edit Mouse

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene. ^[5]

Function

INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164880 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Integrator complex subunit 1". Retrieved 2016-06-11.

Function

References

Further reading