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HIST2H2AA3

From Wikipedia, the free encyclopedia
H2AC18
Identifiers
AliasesH2AC18, H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA, histone cluster 2, H2aa3, histone cluster 2 H2A family member a3, HIST2H2AA3, H2A clustered histone 18, H2AC19
External IDsOMIM: 142720; MGI: 2448283; HomoloGene: 116071; GeneCards: H2AC18; OMA:H2AC18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003516

NM_178212

RefSeq (protein)

NP_001035807
NP_003507

NP_038577
NP_835584

Location (UCSC)Chr 1: 149.84 – 149.84 MbChr 3: 96.15 – 96.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 2-A is a protein that in humans is encoded by the HIST2H2AA3 gene.[5][6][7][8]

Function

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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000288825Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063954Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marashi F, Prokopp K, Stein J, Stein G (April 1984). "Evidence for a human histone gene cluster containing H2B and H2A pseudogenes". Proceedings of the National Academy of Sciences of the United States of America. 81 (7): 1936–40. Bibcode:1984PNAS...81.1936M. doi:10.1073/pnas.81.7.1936. PMC 345411. PMID 6326092.
  6. ^ Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (February 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA and Cell Biology. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821.
  7. ^ Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS (November 2004). "Functional characterization of a human histone gene cluster duplication". Gene. 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID 15527963.
  8. ^ a b "Entrez Gene: HIST2H2AA3 histone cluster 2, H2aa3".

Further reading

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