HIST1H2BI

H2BC10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5KGF
Identifiers
Aliases	H2BC10, H2B/k, H2BFK, histone cluster 1, H2bi, histone cluster 1 H2B family member i, H2B clustered histone 10, HIST1H2BI, H2BC8, H2BC7, H2BC6, H2BC4
External IDs	OMIM: 602807; MGI: 1915274; HomoloGene: 138634; GeneCards: H2BC10; OMA:H2BC10 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,272,931 bp End 26,273,412 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,868,182 bp End 23,876,891 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells Achilles tendon epithelium of colon thymus jejunal mucosa tonsil oral cavity pylorus cartilage tissue epithelium of bronchus Top expressed in blood left colon left lobe of liver seminal vesicula decidua epithelium of stomach Epithelium of choroid plexus intercostal muscle calvaria right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding protein heterodimerization activity identical protein binding Cellular component chromosome nucleosome extracellular exosome nucleus nucleoplasm extracellular space cytosol Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8346 68024 Ensembl ENSG00000278588 ENSMUSG00000018102 UniProt P62807 Q6ZWY9 RefSeq (mRNA) NM_003525 NM_001290380 NM_023422 RefSeq (protein) NP_003517 NP_001368918 NP_001171124 NP_001277459 NP_835501 NP_835503 NP_001277309 NP_075911 Location (UCSC) Chr 6: 26.27 – 26.27 Mb Chr 13: 23.87 – 23.88 Mb PubMed search
Wikidata
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Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BI gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.