Glutamyl-tRNA reductase
| glutamyl-tRNA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.70 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
A glutamyl-tRNA reductase (EC 1.2.1.70) is an enzyme that catalyzes the chemical reaction
- L-glutamate 1-semialdehyde NADP tRNAGlu L-glutamyl-tRNAGlu NADPH H
The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP , and tRNA(Glu), whereas its 3 products are L-glutamyl-tRNA(Glu), NADPH, and H .
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the aldehyde or oxo group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP oxidoreductase (L-glutamyl-tRNAGlu-forming). This enzyme participates in porphyrin and chlorophyll metabolism.
References
[edit]- Von Wettstein D, Gough S, Kannangara CG (1995). "Chlorophyll Biosynthesis". Plant Cell. 7 (7): 1039–1057. doi:10.1105/tpc.7.7.1039. PMC 160907. PMID 12242396.
- Pontoppidan B, Kannangara CG (1994). "Purification and partial characterisation of barley glutamyl-tRNA(Glu) reductase, the enzyme that directs glutamate to chlorophyll biosynthesis". Eur. J. Biochem. 225 (2): 529–37. doi:10.1111/j.1432-1033.1994.00529.x. PMID 7957167.
- Heinz DW, Inokuchi H, Soll D, Jahn D (2002). "Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate". J. Biol. Chem. 277 (50): 48657–63. doi:10.1074/jbc.M206924200. PMID 12370189.
