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GRB14

From Wikipedia, the free encyclopedia
GRB14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGRB14, growth factor receptor bound protein 14
External IDsOMIM: 601524; MGI: 1355324; HomoloGene: 3303; GeneCards: GRB14; OMA:GRB14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303422
NM_004490

NM_016719

RefSeq (protein)

NP_001290351
NP_004481

NP_057928

Location (UCSC)Chr 2: 164.49 – 164.62 MbChr 2: 64.74 – 64.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[5][6]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[6]

Interactions

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GRB14 has been shown to interact with Epidermal growth factor receptor,[7] Fibroblast growth factor receptor 1[8] and TNKS2.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115290Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026888Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.
  6. ^ a b "Entrez Gene: GRB14 growth factor receptor-bound protein 14".
  7. ^ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. 271 (21). UNITED STATES: 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858.
  8. ^ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. 275 (11). UNITED STATES: 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090.
  9. ^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20). United States: 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.

Further reading

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