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Erika L. Pearce

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Erika Pearce
Born1972 (age 51–52)
North Fork, New York, USA
Alma materBSc, Cornell University
PhD, University of Pennsylvania
Awards
Scientific career
Fields
Institutions
Thesis Development of CD8 T cell responses  (2005)
Websitewww.ie-freiburg.mpg.de/pearce

Erika L. Pearce is an American immunologist. She is the Bloomberg Distinguished Professor at the Johns Hopkins University after serving as director and a scientific member at Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. Her work investigates the connection between metabolism and immune cell function with a particular focus on the regulation of T-cells. In 2018, she was awarded the Leibniz Prize for her "outstanding work in metabolism and inflammation research."

Early life and education

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Pearce was born in 1972,[1] and grew up in North Fork, Long Island, New York.[2] She completed her Bachelor of Science degree at Cornell University in 1998 and earned her PhD in cell and molecular biology from the University of Pennsylvania in 2005.[3] While completing her postdoctoral studies at the University of Pennsylvania, Pearce began her research into how cellular metabolic processes govern immune responses to infection and cancer.[4]

Career

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Upon completing her postdoctoral studies, Pearce joined the Trudeau Institute in New York City from 2009 until 2011. She left the non-profit in 2011 to become an assistant professor in the Department of Pathology and Immunology at the Washington University School of Medicine (WUSM) in St. Louis.[1] During her tenure at WUSM, Pearce expanded on her earlier research into memory T cells. In 2012, her research team found that the production of additional mitochondria is triggered by interleukin-15. She also found that genetically manipulating T cell's mitochondria could cause a higher percentage of undifferentiated T cells to become memory cells.[5] Pearce and her colleagues also found evidence that suggested cancer cells could disable T cells ability to fight off tumors and some kinds of infection. Her research team found that withholding sugar from T cells, the cells no longer produced interferon gamma.[6] In March 2014, Pearce was promoted to the rank of associate professor of pathology and immunology at WUSM.[7] In her new role, Pearce received two grants to assist her research into cellular metabolism in immunity to infection. She received a grant from the Burroughs Wellcome Fund[8] and the National Cancer Institute of the National Institutes of Health.[9]

Pearce left North America in September 2015 to become the director and a scientific member at Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany.[10] In 2018, she was awarded the Leibniz Prize for her "outstanding work in metabolism and inflammation research."[1] Pearce returned to the United States in 2022 to become the Bloomberg Distinguished Professor at Johns Hopkins University.[11]

Publications

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As of 2021, Pearce has more than 18,000 citations in Google Scholar and an h-index of 49.[12]

Highly cited articles (more than 1000 citations)

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  • Gubin, Matthew M.; Zhang, Xiuli; Schuster, Heiko; Caron, Etienne; Ward, Jeffrey P.; Noguchi, Takuro; Ivanova, Yulia; Hundal, Jasreet; Arthur, Cora D.; Krebber, Willem-Jan; Mulder, Gwenn E.; Toebes, Mireille; Vesely, Matthew D.; Lam, Samuel S. K.; Korman, Alan J.; Allison, James P.; Freeman, Gordon J.; Sharpe, Arlene H.; Pearce, Erika L.; Schumacher, Ton N.; Aebersold, Ruedi; Rammensee, Hans-Georg; Melief, Cornelis J. M.; Mardis, Elaine R.; Gillanders, William E.; Artyomov, Maxim N.; Schreiber, Robert D. (26 November 2014). "Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens". Nature. 515 (7528). Springer Science and Business Media LLC: 577–581. Bibcode:2014Natur.515..577G. doi:10.1038/nature13988. ISSN 0028-0836. PMC 4279952. PMID 25428507.
  • Chang, Chih-Hao; Qiu, Jing; O’Sullivan, David; Buck, Michael D.; Noguchi, Takuro; Curtis, Jonathan D.; Chen, Qiongyu; Gindin, Mariel; Gubin, Matthew M.; van der Windt, Gerritje J.W.; Tonc, Elena; Schreiber, Robert D.; Pearce, Edward J.; Pearce, Erika L. (2015). "Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression". Cell. 162 (6). Elsevier BV: 1229–1241. doi:10.1016/j.cell.2015.08.016. ISSN 0092-8674. PMC 4864363. PMID 26321679. S2CID 10739910.
  • Chang, Chih-Hao; Curtis, Jonathan D.; Maggi, Leonard B.; Faubert, Brandon; Villarino, Alejandro V.; O’Sullivan, David; Huang, Stanley Ching-Cheng; van der Windt, Gerritje J.W.; Blagih, Julianna; Qiu, Jing; Weber, Jason D.; Pearce, Edward J.; Jones, Russell G.; Pearce, Erika L. (2013). "Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis". Cell. 153 (6). Elsevier BV: 1239–1251. doi:10.1016/j.cell.2013.05.016. ISSN 0092-8674. PMC 3804311. PMID 23746840.
  • Pearce, Erika L.; Walsh, Matthew C.; Cejas, Pedro J.; Harms, Gretchen M.; Shen, Hao; Wang, Li-San; Jones, Russell G.; Choi, Yongwon (3 June 2009). "Enhancing CD8 T-cell memory by modulating fatty acid metabolism". Nature. 460 (7251). Springer Science and Business Media LLC: 103–107. Bibcode:2009Natur.460..103P. doi:10.1038/nature08097. ISSN 0028-0836. PMC 2803086. PMID 19494812.
  • van der Windt, Gerritje J.W.; Everts, Bart; Chang, Chih-Hao; Curtis, Jonathan D.; Freitas, Tori C.; Amiel, Eyal; Pearce, Edward J.; Pearce, Erika L. (2012). "Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8 T Cell Memory Development". Immunity. 36 (1). Elsevier BV: 68–78. doi:10.1016/j.immuni.2011.12.007. ISSN 1074-7613. PMC 3269311. PMID 22206904.

See also

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References

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  1. ^ a b c "Leibniz Prize 2018 for Erika Pearce". Max Planck Institute. December 14, 2017. Retrieved November 21, 2022.
  2. ^ O’Donnell, Marie Anne (July 2, 2018). "Erika Pearce: Fitting metabolism and immunity together, to a T". Journal of Cell Biology. 21 (7): 2223–2224. doi:10.1083/jcb.201806055. PMC 6028542. PMID 29921602.
  3. ^ "Erika L. Pearce, Ph.D." Johns Hopkins University. Retrieved November 21, 2022.
  4. ^ "Diabetes drug may help fight cancer, mouse study suggests". Canadian Broadcasting Corporation. June 3, 2009. Retrieved November 21, 2022.
  5. ^ Purdy, Michael C. (January 18, 2012). "Immune system memory cells have trick for self preservation". Washington University in St. Louis. Retrieved November 21, 2022.
  6. ^ Purdy, Michael C. (June 6, 2013). "Tumors disable immune cells by using up sugar". Washington University in St. Louis. Retrieved November 21, 2022.
  7. ^ "TRUSTEES GRANT FACULTY PROMOTIONS, TENURE". Washington University in St. Louis. April 21, 2014. Archived from the original on November 22, 2022. Retrieved November 21, 2022.
  8. ^ Campbell, Russ (June 15, 2014). "BWF Invests $21 Million In Biomedical Research". Burroughs Wellcome Fund. Retrieved November 21, 2022.
  9. ^ "Medical researcher Pearce receives nearly $1.8 million in grants". Washington University in St. Louis. August 11, 2015. Retrieved November 21, 2022.
  10. ^ "Erika Pearce – new director at the MPI-IE". Max-Planck-Institute of Immunobiology and Epigenetics. October 12, 2015. Retrieved November 21, 2022.
  11. ^ Cruickshank, Saralyn (April 6, 2021). "Molecular biologist Erika Pearce joins Johns Hopkins as Bloomberg Distinguished Professor". Johns Hopkins University. Retrieved November 21, 2022.
  12. ^ Erika L. Pearce publications indexed by Google Scholar
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