DHX15

DHX15
Identifiers
Aliases	DHX15, DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p, DEAH-box helicase 15, hPrp43
External IDs	OMIM: 603403; MGI: 1099786; HomoloGene: 1040; GeneCards: DHX15; OMA:DHX15 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	24,584,554 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	52,347,856 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; tibia; ; germinal epithelium; ; mucosa of sigmoid colon; ; visceral pleura; ; skin of hip; ; parietal pleura; ; embryo; ; ventricular zone; ; skin of thigh;
	Top expressed in
	primitive streak; ; Gonadal ridge; ; mandibular prominence; ; maxillary prominence; ; abdominal wall; ; hair follicle; ; medial ganglionic eminence; ; cumulus cell; ; human fetus; ; somite;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity; nucleotide binding; double-stranded RNA binding; protein binding; ATP binding; helicase activity; hydrolase activity; nucleic acid binding; RNA binding; 3'-5' RNA helicase activity;
Cellular component	U12-type spliceosomal complex; nucleolus; U2-type post-mRNA release spliceosomal complex; cytoplasm; nucleus; nucleoplasm; nuclear speck;
Biological process	mRNA processing; response to alkaloid; response to toxic substance; RNA splicing; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	1665
	13204
	ENSG00000109606
	ENSMUSG00000029169
	O43143
	O35286
	NM_001358
	NM_001042620; NM_007839
	NP_001349
	NP_001036085; NP_031865
	Wikidata
View/Edit Human	View/Edit Mouse

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.^[5]^[6]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.^[6] It may have tumor suppressor activity.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109606 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029169 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.
^ ^a ^b "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".
^ Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi:10.1038/bjc.2017.273. PMC 5672939. PMID 28829764.

Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID 9747670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA. 8 (11): 1428–43. doi:10.1017/S1355838202021076. PMC 1370349. PMID 12458796.
Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. doi:10.1128/MCB.14.11.7611. PMC 359297. PMID 7935475.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109606 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029169 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9388478-5] Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.

[entrez-6] "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".

[sitobmj2017-7] Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi:10.1038/bjc.2017.273. PMC 5672939. PMID 28829764.

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References

Further reading