Deoxycytidine triphosphate

Deoxycytidine triphosphate
Names
	IUPAC name 2′-Deoxycytidine 5′-(tetrahydrogen triphosphate)
	Systematic IUPAC name O1-{[(2R,3S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
CAS Number	2056-98-6 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16311;
ChemSpider	58601 ;
ECHA InfoCard	100.016.504
PubChem CID	65091;
CompTox Dashboard (EPA)	DTXSID60942755 DTXSID50908042, DTXSID60942755 ;
	InChI InChI=1S/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6 ,8 /m0/s1 Key: RGWHQCVHVJXOKC-SHYZEUOFSA-N ; InChI=1/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6 ,8 /m0/s1 Key: RGWHQCVHVJXOKC-SHYZEUOFBW;
	SMILES C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O;
Properties
Chemical formula	C9H16N3O13P3
Molar mass	467.156 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that contains the pyrimidine base cytosine. The triphosphate group contains high-energy phosphoanhydride bonds, which liberate energy when hydrolized.

DNA polymerase enzymes use this energy to incorporate deoxycytidine into a newly synthesized strand of DNA. A chemical equation can be written that represents the process:

(DNA)_n dCTP ↔ (DNA)_n-C PP_i

That is, dCTP has the PP_i (pyrophosphate) cleaved off and the dCMP is incorporated into the DNA strand at the 3' end. Subsequent hydrolysis of the PP_i drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain.

Like other nucleoside triphosphates, manufacturers recommend that dCTP be stored in aqueous solution at −20 °C.^[1]

References

^ "Definitive Guide to dNTPs" (PDF). Retrieved July 29, 2017.

External links

Definitive Guide to dNTPs

[1] "Definitive Guide to dNTPs" (PDF). Retrieved July 29, 2017.

[1]

See also

References

External links