CXCL15

Cxcl15
Identifiers
Aliases	chemokine (C-X-C motif) ligand 15Il8Scyb15lungkineweche
External IDs	GeneCards: [1]; OMA:- orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	90,950,926 bp
RNA expression pattern
	Top expressed in
	left lung lobe; ; right lung lobe; ; trachea; ; cervix; ; sexually immature organism; ; mammary gland; ; external carotid artery; ; lobe of prostate; ; genital tubercle; ; nucleus accumbens;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	chemokine activity; cytokine activity; CXCR3 chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; response to lipopolysaccharide; inflammatory response; regulation of cell population proliferation; immune response; neutrophil chemotaxis; positive regulation of leukocyte chemotaxis; defense response; T cell chemotaxis; regulation of signaling receptor activity; hemopoiesis; leukocyte chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	20309
	n/a
	ENSMUSG00000029375
	n/a
	Q9WVL7
	n/a
	NM_011339
	n/a
	NP_035469
	n/a
	Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,^[2] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.^[3] The gene for CXCL15 is found on mouse chromosome 5.

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. doi:10.4049/jimmunol.162.9.5490. PMID 10228029.
^ Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol. 162 (9): 5490–7. doi:10.4049/jimmunol.162.9.5490. PMID 10228029.

[3] Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem. 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.

[1]

[2]

[3]