CEP97

CEP97
Identifiers
Aliases	CEP97, 2810403B08Rik, LRRIQ2, centrosomal protein 97
External IDs	OMIM: 615864; MGI: 1921451; HomoloGene: 11579; GeneCards: CEP97; OMA:CEP97 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	101,770,562 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	55,755,218 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; endothelial cell; ; mucosa of paranasal sinus; ; inferior ganglion of vagus nerve; ; oocyte; ; internal globus pallidus; ; secondary oocyte; ; superior vestibular nucleus; ; subthalamic nucleus; ; ventricular zone;
	Top expressed in
	Rostral migratory stream; ; hand; ; otolith organ; ; utricle; ; thymus; ; cumulus cell; ; blood; ; pineal gland; ; ciliary body; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; calmodulin binding;
Cellular component	centrosome; cytoskeleton; microtubule organizing center; cytoplasm; cytosol; protein-containing complex;
Biological process	cell projection organization; negative regulation of cilium assembly; regulation of mitotic spindle assembly; ciliary basal body-plasma membrane docking;
	Sources:Amigo / QuickGO
Orthologs
	79598
	74201
	ENSG00000182504
	ENSMUSG00000022604
	Q8IW35
	Q9CZ62
	NM_001303401; NM_024548
	NM_001159364; NM_001159365; NM_001159366; NM_028815
	NP_001290330; NP_078824
	NP_001152836; NP_001152837; NP_001152838; NP_083091
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein of 97 kDa (Cep97), also known as leucine-rich repeat and IQ domain-containing protein 2 (LRRIQ2), is a protein that in humans is encoded by the CEP97 gene.^[5]

Cep97 along with CP110 inhibit generation of cilia.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182504 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: centrosomal protein 97kDa".
^ Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell. 130 (4): 678–690. doi:10.1016/j.cell.2007.06.027. PMID 17719545. S2CID 17974875.678-690&rft.date=2007-08&rft_id=https://api.semanticscholar.org/CorpusID:17974875#id-name=S2CID&rft_id=info:pmid/17719545&rft_id=info:doi/10.1016/j.cell.2007.06.027&rft.aulast=Spektor&rft.aufirst=A&rft.au=Tsang, WY&rft.au=Khoo, D&rft.au=Dynlacht, BD&rft_id=https://doi.org/10.1016%2Fj.cell.2007.06.027&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">

External links

Human CEP97 genome location and CEP97 gene details page in the UCSC Genome Browser.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-2127&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-174&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">
Svendsen JM, Smogorzewska A, Sowa ME, et al. (2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63–77. doi:10.1016/j.cell.2009.06.030. PMC 2720686. PMID 19596235.63-77&rft.date=2009&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720686#id-name=PMC&rft_id=info:pmid/19596235&rft_id=info:doi/10.1016/j.cell.2009.06.030&rft.aulast=Svendsen&rft.aufirst=JM&rft.au=Smogorzewska, A&rft.au=Sowa, ME&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720686&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-156&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">
Bettencourt-Dias M, Carvalho-Santos Z (2008). "Double life of centrioles: CP110 in the spotlight". Trends Cell Biol. 18 (1): 8–11. doi:10.1016/j.tcb.2007.11.002. PMID 18068367.8-11&rft.date=2008&rft_id=info:doi/10.1016/j.tcb.2007.11.002&rft_id=info:pmid/18068367&rft.aulast=Bettencourt-Dias&rft.aufirst=M&rft.au=Carvalho-Santos, Z&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.499-508&rft.date=2008&rft_id=info:doi/10.1074/mcp.M700325-MCP200&rft_id=info:pmid/18029348&rft.aulast=Barbe&rft.aufirst=L&rft.au=Lundberg, E&rft.au=Oksvold, P&rft_id=https://doi.org/10.1074%2Fmcp.M700325-MCP200&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">
Tsang WY, Spektor A, Vijayakumar S, et al. (2009). "Cep76, a centrosomal protein that specifically restrains centriole reduplication". Dev. Cell. 16 (5): 649–660. doi:10.1016/j.devcel.2009.03.004. PMC 4062978. PMID 19460342.649-660&rft.date=2009&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062978#id-name=PMC&rft_id=info:pmid/19460342&rft_id=info:doi/10.1016/j.devcel.2009.03.004&rft.aulast=Tsang&rft.aufirst=WY&rft.au=Spektor, A&rft.au=Vijayakumar, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062978&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182504 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: centrosomal protein 97kDa".

[pmid17719545-6] Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell. 130 (4): 678–690. doi:10.1016/j.cell.2007.06.027. PMID 17719545. S2CID 17974875.678-690&rft.date=2007-08&rft_id=https://api.semanticscholar.org/CorpusID:17974875#id-name=S2CID&rft_id=info:pmid/17719545&rft_id=info:doi/10.1016/j.cell.2007.06.027&rft.aulast=Spektor&rft.aufirst=A&rft.au=Tsang, WY&rft.au=Khoo, D&rft.au=Dynlacht, BD&rft_id=https://doi.org/10.1016%2Fj.cell.2007.06.027&rfr_id=info:sid/en.wikipedia.org:CEP97" class="Z3988">

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v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

References

External links

Further reading