CEP68

CEP68
Identifiers
Aliases	CEP68, KIAA0582, centrosomal protein 68
External IDs	OMIM: 616889; MGI: 2667663; HomoloGene: 65235; GeneCards: CEP68; OMA:CEP68 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	65,087,004 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,199,429 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; glutes; ; Skeletal muscle tissue of rectus abdominis; ; skin of hip; ; skin of thigh; ; superficial temporal artery; ; parietal pleura; ; urethra; ; nipple;
	Top expressed in
	Rostral migratory stream; ; digastric muscle; ; extraocular muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; soleus muscle; ; temporal muscle; ; abdominal wall; ; vastus lateralis muscle; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein kinase binding; protein binding;
Cellular component	cell junction; nucleus; centrosome; microtubule organizing center; cytoskeleton; cytoplasm; cytosol;
Biological process	protein localization to organelle; centriole-centriole cohesion; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
	23177
	216543
	ENSG00000011523
	ENSMUSG00000044066
	Q76N32
	Q8C0D9
	NM_015147; NM_001319100; NM_001319101
	NM_172260
	NP_001306029; NP_001306030; NP_055962
	NP_758464
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.^[5]^[6]^[7]^[8] CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011523 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.31-9&rft.date=1998-02&rft_id=info:doi/10.1093/dnares/5.1.31&rft_id=info:pmid/9628581&rft.aulast=Nagase&rft.aufirst=T&rft.au=Ishikawa, K&rft.au=Miyajima, N&rft.au=Tanaka, A&rft.au=Kotani, H&rft.au=Nomura, N&rft.au=Ohara, O&rft_id=https://doi.org/10.1093%2Fdnares%2F5.1.31&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">
^ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.1097-108&rft.date=1998-11&rft_id=info:doi/10.1101/gr.8.11.1097&rft_id=info:pmid/9847074&rft.aulast=Sanger Centre&rft.aufirst=The&rft.au=Washington University Genome Sequencing Cente, The&rft_id=https://doi.org/10.1101%2Fgr.8.11.1097&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">
^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.570-4&rft.date=2003-12&rft_id=info:doi/10.1038/nature02166&rft_id=https://api.semanticscholar.org/CorpusID:4427303#id-name=S2CID&rft_id=info:pmid/14654843&rft_id=info:bibcode/2003Natur.426..570A&rft.aulast=Andersen&rft.aufirst=JS&rft.au=Wilkinson, CJ&rft.au=Mayor, T&rft.au=Mortensen, P&rft.au=Nigg, EA&rft.au=Mann, M&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">
^ "Entrez Gene: CEP68 centrosomal protein 68kDa".
^ Graser S, Stierhof YD, Nigg EA (Dec 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621. S2CID 7307094.4321-31&rft.date=2007-12&rft_id=https://api.semanticscholar.org/CorpusID:7307094#id-name=S2CID&rft_id=info:pmid/18042621&rft_id=info:doi/10.1242/jcs.020248&rft.aulast=Graser&rft.aufirst=S&rft.au=Stierhof, YD&rft.au=Nigg, EA&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">

External links

Human CEP68 genome location and CEP68 gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.99-106&rft.date=2002-06&rft_id=info:doi/10.1093/dnares/9.3.99&rft_id=info:pmid/12168954&rft.aulast=Nakajima&rft.aufirst=D&rft.au=Okazaki, N&rft.au=Yamakawa, H&rft.au=Kikuno, R&rft.au=Ohara, O&rft.au=Nagase, T&rft_id=https://doi.org/10.1093%2Fdnares%2F9.3.99&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.205-20&rft.date=2002-06&rft_id=info:pmid/12107410&rft.aulast=Wistow&rft.aufirst=G&rft.au=Bernstein, SL&rft.au=Wyatt, MK&rft.au=Fariss, RN&rft.au=Behal, A&rft.au=Touchman, JW&rft.au=Bouffard, G&rft.au=Smith, D&rft.au=Peterson, K&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">
Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK (Feb 2007). "Rate of evolution in brain-expressed genes in humans and other primates". PLOS Biology. 5 (2): e13. doi:10.1371/journal.pbio.0050013. PMC 1717015. PMID 17194215.
Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516. S2CID 23944956.2384-97&rft.date=2007-07&rft_id=https://api.semanticscholar.org/CorpusID:23944956#id-name=S2CID&rft_id=info:pmid/17570516&rft_id=info:doi/10.1002/pmic.200600968&rft.aulast=Chen&rft.aufirst=Y&rft.au=Low, TY&rft.au=Choong, LY&rft.au=Ray, RS&rft.au=Tan, YL&rft.au=Toy, W&rft.au=Lin, Q&rft.au=Ang, BK&rft.au=Wong, CH&rft.au=Lim, S&rft.au=Li, B&rft.au=Hew, CL&rft.au=Sze, NS&rft.au=Druker, BJ&rft.au=Lim, YP&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011523 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9628581-5] Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.31-9&rft.date=1998-02&rft_id=info:doi/10.1093/dnares/5.1.31&rft_id=info:pmid/9628581&rft.aulast=Nagase&rft.aufirst=T&rft.au=Ishikawa, K&rft.au=Miyajima, N&rft.au=Tanaka, A&rft.au=Kotani, H&rft.au=Nomura, N&rft.au=Ohara, O&rft_id=https://doi.org/10.1093%2Fdnares%2F5.1.31&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">

[pmid9847074-6] Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.1097-108&rft.date=1998-11&rft_id=info:doi/10.1101/gr.8.11.1097&rft_id=info:pmid/9847074&rft.aulast=Sanger Centre&rft.aufirst=The&rft.au=Washington University Genome Sequencing Cente, The&rft_id=https://doi.org/10.1101%2Fgr.8.11.1097&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">

[pmid14654843-7] Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.570-4&rft.date=2003-12&rft_id=info:doi/10.1038/nature02166&rft_id=https://api.semanticscholar.org/CorpusID:4427303#id-name=S2CID&rft_id=info:pmid/14654843&rft_id=info:bibcode/2003Natur.426..570A&rft.aulast=Andersen&rft.aufirst=JS&rft.au=Wilkinson, CJ&rft.au=Mayor, T&rft.au=Mortensen, P&rft.au=Nigg, EA&rft.au=Mann, M&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">

[entrez-8] "Entrez Gene: CEP68 centrosomal protein 68kDa".

[9] Graser S, Stierhof YD, Nigg EA (Dec 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621. S2CID 7307094.4321-31&rft.date=2007-12&rft_id=https://api.semanticscholar.org/CorpusID:7307094#id-name=S2CID&rft_id=info:pmid/18042621&rft_id=info:doi/10.1242/jcs.020248&rft.aulast=Graser&rft.aufirst=S&rft.au=Stierhof, YD&rft.au=Nigg, EA&rfr_id=info:sid/en.wikipedia.org:CEP68" class="Z3988">

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v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

References

External links

Further reading