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CD79B

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CD79B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD79B, AGM6, B29, IGB, CD79b molecule, Igbeta
External IDsOMIM: 147245; MGI: 96431; HomoloGene: 521; GeneCards: CD79B; OMA:CD79B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

974

15985

Ensembl

ENSG00000007312

ENSMUSG00000040592

UniProt

P40259

P15530

RefSeq (mRNA)

NM_000626
NM_001039933
NM_021602
NM_001329050

NM_008339
NM_001313939

RefSeq (protein)

NP_000617
NP_001035022
NP_001315979
NP_067613

NP_001300868
NP_032365

Location (UCSC)Chr 17: 63.93 – 63.93 MbChr 11: 106.2 – 106.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.[5]

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

Further reading

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  • Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.97-121&rft.date=1992&rft_id=info:doi/10.1146/annurev.iy.10.040192.000525&rft_id=info:pmid/1591006&rft.au=Reth+M&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761. S2CID 23910309.1621-5&rft.date=1992&rft_id=https://api.semanticscholar.org/CorpusID:23910309#id-name=S2CID&rft_id=info:pmid/1534761&rft_id=info:doi/10.1002/eji.1830220641&rft.aulast=Müller&rft.aufirst=B&rft.au=Cooper,+L&rft.au=Terhorst,+C&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031. S2CID 25093082.812-6&rft.date=1994&rft_id=https://api.semanticscholar.org/CorpusID:25093082#id-name=S2CID&rft_id=info:pmid/7512031&rft_id=info:doi/10.1002/eji.1830240406&rft.aulast=Lankester&rft.aufirst=AC&rft.au=van+Schijndel,+GM&rft.au=Cordell,+JL&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.419-27&rft.date=1994&rft_id=info:doi/10.1016/0161-5890(94)90061-2&rft_id=info:pmid/7514267&rft.aulast=Vasile&rft.aufirst=S&rft.au=Coligan,+JE&rft.au=Yoshida,+M&rft.au=Seon,+BK&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. Biol. Chem. 269 (25): 17238–44. doi:10.1016/S0021-9258(17)32545-0. PMID 7516335.17238-44&rft.date=1994&rft_id=info:doi/10.1016/S0021-9258(17)32545-0&rft_id=info:pmid/7516335&rft.aulast=Brown&rft.aufirst=VK&rft.au=Ogle,+EW&rft.au=Burkhardt,+AL&rft_id=https://doi.org/10.1016%2FS0021-9258%2817%2932545-0&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.11590-4&rft.date=1995&rft_id=info:doi/10.1074/jbc.270.19.11590&rft_id=info:pmid/7538118&rft.aulast=Rowley&rft.aufirst=RB&rft.au=Burkhardt,+AL&rft.au=Chao,+HG&rft_id=https://doi.org/10.1074%2Fjbc.270.19.11590&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMC 2192043. PMID 7539038.2077-84&rft.date=1995&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192043#id-name=PMC&rft_id=info:pmid/7539038&rft_id=info:doi/10.1084/jem.181.6.2077&rft.aulast=Pani&rft.aufirst=G&rft.au=Kozlowski,+M&rft.au=Cambier,+JC&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192043&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.2–3&rft.pages=97-103&rft.date=1995&rft_id=info:doi/10.1016/0165-2478(94)00199-2&rft_id=info:pmid/7541024&rft.aulast=Müller&rft.aufirst=B&rft.au=Cooper,+L&rft.au=Terhorst,+C&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.27072-8&rft.date=1995&rft_id=info:doi/10.1074/jbc.270.45.27072&rft_id=info:pmid/7592958&rft.aulast=Saouaf&rft.aufirst=SJ&rft.au=Kut,+SA&rft.au=Fargnoli,+J&rft_id=https://doi.org/10.1074%2Fjbc.270.45.27072&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.651-9&rft.date=1995&rft_id=info:doi/10.1016/0161-5890(95)00023-8&rft_id=info:pmid/7643857&rft.aulast=Hashimoto&rft.aufirst=S&rft.au=Chiorazzi,+N&rft.au=Gregersen,+PK&rft_id=https://doi.org/10.1016%2F0161-5890%2895%2900023-8&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics. 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081. S2CID 6966566.145-9&rft.date=1994&rft_id=https://api.semanticscholar.org/CorpusID:6966566#id-name=S2CID&rft_id=info:pmid/7913081&rft_id=info:doi/10.1007/BF00188178&rft.aulast=Hashimoto&rft.aufirst=S&rft.au=Chiorazzi,+N&rft.au=Gregersen,+PK&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. doi:10.4049/jimmunol.153.6.2369. PMID 8077654. S2CID 22158525.2369-80&rft.date=1994&rft_id=https://api.semanticscholar.org/CorpusID:22158525#id-name=S2CID&rft_id=info:pmid/8077654&rft_id=info:doi/10.4049/jimmunol.153.6.2369&rft.aulast=Gold&rft.aufirst=MR&rft.au=Chiu,+R&rft.au=Ingham,+RJ&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano,+S&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491–8. doi:10.4049/jimmunol.150.2.491. PMID 8419481. S2CID 36149482.491-8&rft.date=1993&rft_id=https://api.semanticscholar.org/CorpusID:36149482#id-name=S2CID&rft_id=info:pmid/8419481&rft_id=info:doi/10.4049/jimmunol.150.2.491&rft.aulast=Hashimoto&rft.aufirst=S&rft.au=Gregersen,+PK&rft.au=Chiorazzi,+N&rft_id=https://doi.org/10.4049%2Fjimmunol.150.2.491&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.187-92&rft.date=1993&rft_id=info:doi/10.1006/geno.1993.1157&rft_id=info:pmid/8486355&rft.aulast=Wood&rft.aufirst=WJ&rft.au=Thompson,+AA&rft.au=Korenberg,+J&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5" flanking sequences controlling human B29 gene expression". Blood. 87 (2): 666–73. doi:10.1182/blood.V87.2.666.bloodjournal872666. PMID 8555489.666-73&rft.date=1996&rft_id=info:doi/10.1182/blood.V87.2.666.bloodjournal872666&rft_id=info:pmid/8555489&rft.aulast=Thompson&rft.aufirst=AA&rft.au=Wood,+WJ&rft.au=Gilly,+MJ&rft_id=https://doi.org/10.1182%2Fblood.V87.2.666.bloodjournal872666&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia. 10 (5): 769–73. PMID 8656670.769-73&rft.date=1996&rft_id=info:pmid/8656670&rft.aulast=Astsaturov&rft.aufirst=IA&rft.au=Matutes,+E&rft.au=Morilla,+R&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.151-6&rft.date=1996&rft_id=info:doi/10.1016/0165-2478(95)00071-X&rft_id=info:pmid/8747711&rft.aulast=Koyama&rft.aufirst=M&rft.au=Nakamura,+T&rft.au=Higashihara,+M&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
  • Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". J. Immunol. 158 (7): 3062–9. doi:10.4049/jimmunol.158.7.3062. PMID 9120258. S2CID 20717278.3062-9&rft.date=1997&rft_id=https://api.semanticscholar.org/CorpusID:20717278#id-name=S2CID&rft_id=info:pmid/9120258&rft_id=info:doi/10.4049/jimmunol.158.7.3062&rft.aulast=Carter&rft.aufirst=RH&rft.au=Doody,+GM&rft.au=Bolen,+JB&rft.au=Fearon,+DT&rft_id=https://doi.org/10.4049%2Fjimmunol.158.7.3062&rfr_id=info:sid/en.wikipedia.org:CD79B" class="Z3988">
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