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AP3D1

From Wikipedia, the free encyclopedia
AP3D1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAP3D1, ADTD, hBLVR, adaptor related protein complex 3 delta 1 subunit, HPS10, adaptor related protein complex 3 subunit delta 1
External IDsOMIM: 607246; MGI: 107734; HomoloGene: 2926; GeneCards: AP3D1; OMA:AP3D1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077523
NM_001261826
NM_003938
NM_001374799

NM_007460

RefSeq (protein)

NP_001248755
NP_003929
NP_001361728

NP_031486

Location (UCSC)Chr 19: 2.1 – 2.16 MbChr 10: 80.54 – 80.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.[5][6][7]

Function

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AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM][7]

Interactions

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AP3D1 has been shown to interact with SYBL1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065000Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020198Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC 2139840. PMID 9151686.
  6. ^ Ooi CE, Moreira JE, Dell'Angelica EC, Poy G, Wassarman DA, Bonifacino JS (Aug 1997). "Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet". The EMBO Journal. 16 (15): 4508–18. doi:10.1093/emboj/16.15.4508. PMC 1170077. PMID 9303295.
  7. ^ a b "Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit".
  8. ^ Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proceedings of the National Academy of Sciences of the United States of America. 100 (15): 9011–6. Bibcode:2003PNAS..100.9011M. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
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Further reading

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