Ursúa, Ursua, Urzúa or Urzua is a Basque surname. Notable people with the surname include:
- Antonio María de Bucareli y Ursúa (1717–1779), Spanish military officer, governor of Cuba, viceroy of New Spain
- Francisco de Paula Bucareli y Ursua (1708–1780), his brother, Governor of the Rio de la Plata, viceroy of Navarre
- Domingo Vega Urzúa, also known as Americo, Chilean musician
- Luis Urzúa, Chilean miner, and shift foreman and leader of the trapped miners during the 2010 Copiapó mining accident
- María José Urzúa, Chilean actress
- Martín de Ursúa y Arizmendi, count of Lizárraga (1653–1715), Spanish conquistador during the final conquest of the Maya in 1697
- Pedro de Ursúa (1526–1561), Spanish conquistador in the 16th century
- Pedro Verdugo de Albornoz Ursúa (1657–1720), Spanish noble and academician