Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.[1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.
| unc-51-like kinase 2 (C. elegans) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ULK2 | ||||||
| NCBI gene | 9706 | ||||||
| HGNC | 13480 | ||||||
| OMIM | 608650 | ||||||
| RefSeq | NM_014683 | ||||||
| UniProt | Q8IYT8 | ||||||
| Other data | |||||||
| EC number | 2.7.11.1 | ||||||
| Locus | Chr. 17 p11.2 | ||||||
| |||||||
Structure and function
editThis gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.[3]
References
edit- ^ Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene. 18 (43): 5850–9. doi:10.1038/sj.onc.1202988. PMID 10557072.
- ^ "Entrez Gene: ULK2".
- ^ Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.
External links
edit- ULK2 protein, mouse at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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