Talk:Thyroid hormones

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Untitled

This article was produced from a merge of thyroxine and triiodothyronine. tb 00:44, 21 Mar 2004 (UTC)

This was then merged with the existing article at thyroid hormones. (Note the s.) tb 01:06, 21 Mar 2004 (UTC)

... which is really funny because now there are thyroxine and triiodothyronine articles again. -R 76.248.234.11 (talk) 07:54, 7 September 2008 (UTC)

Absorbed well by the "gut"? That sounds a bit colloquial. I'm changing it to "digestive system".

1. I've been told that the word is used in medicine. I'm reverting my change.

'Gut' is perfectly acceptable medical/anatomical terminology for the upper and lower bowels, and more accurate here than 'digestive system' which includes the orophrarynx from which the thyroid hormones aren't absorbed. Kay Dekker 18:26, 26 January 2006 (UTC)

Could we get some more specifics, especially in the "function" area?

I agree more specifics required. I'd like cites for the 20 to 1 release ratio and several other "facts", the references might include details like species involved ;) However I think the lack of specifics in function is because it isn't fully understood. Things of this kind are often established by removing it and seeing what breaks, and in the case of thyroid hormone lots breaks. So except for very specific pathways identified, the answer is a vague "metabolism". The T3 article currently has some more specifics, but these hormones have been around a long time, and different tissues have evolved different ways of exploiting their effects. I suspect it might be more useful to follow the advice in "merger" below and give effects against specific chemical compounds, whilst this article should describe the general process of conversion from one to other, perhaps how the process compares to other endocrine processes, how it varies between species. i.e. paint a bigger picture.

Species?

A large number of statements give precise information which I presume, or references suggest, is applicable to humans. I think this should be made explicit, the hormone is common to all mammals, I believe all vertebrates(?), and some invertebrate (e.g. Lampreys cf: endostyle). Almost all multicellular animals and many plants use Iodine containing compounds for related purposes. — Preceding unsigned comment added by 84.45.158.52 (talk) 20:44, 28 June 2011 (UTC)

Thyroglobulin?

I think the page on Thyroglobulin could useuflly be absorbed here as well.Midgley 01:38, 10 January 2006 (UTC)

Other uses?

I was perscribed this as a way to boost the effectiveness of an SSRI. Does anyone know much about this practice and how it works? — Soupisgoodfood 14:23, 5 March 2006 (UTC)

Mispelling?

iodothyronamineagafdg I think this is mispelled, but I don't know what is correct. Anybody else know? —The preceding unsigned comment was added by Jasonco (talk • contribs) 01:32, 26 January 2007 (UTC).

Merger

It has been suggested that triiodothyronine be merged into thyroid hormone. I believe they should not be merged. We have a rule at WP:CHEMS - one article per chemical compound. Triiodothyronine is a single compound and thus should remain a separate article from thyroxine.

The thyroid hormone article is fine, but there should be separate articles for each of the compounds mentioned - there needs to be a chembox for each one, where data such as molecular formula are available.

Ben 23:05, 7 February 2007 (UTC)

I agree - I don't think the articles should be merged. --Arcadian 23:30, 14 February 2007 (UTC)

I also think these two compounds deserve their own article. Since it's been agreed upon for about two months that the merger should not go ahead, I'm removing the requests to merge. KBi 04:42, 12 April 2007 (UTC)

This was a bad idea. Thankfully, the triiodothyronine article is still there - with useful and interesting chemical information unrelated to thyroid tests and function. The Thyroxine article should be put back. There is little useful chemical information here for thyroxine - and there should not be - it belongs in a restored levothyroxine page. Who can revert this? 206.112.75.195 (talk) 18:38, 10 August 2015 (UTC)mjd

The diagrams

Is there some valid reason that the two molecular diagrams are rendered differently? Or is it just that they came from different sources?

Looking at triiodothyronine and thyroxine bond by bond, I seem to find that they differ by exactly one iodine atom. This would be quite obvious if they were oriented in the same way and used similar conventions for the bonds in the neighborhood of the amine group. Not a big deal, of course, but there's a failure of clarity here; unless, that is, the different drawings are expressing some actual chemical difference beyond a one-atom substitution. Dandrake 00:16, 19 June 2007 (UTC)Ď

Risks of refusing therapy

This paragraph isn't very wikipedia-like. If there are no objections, I'll remove it next week. —Preceding unsigned comment added by 129.125.182.109 (talk) 14:41, 17 April 2009 (UTC)

I agree. --Miczilla (talk) 09:56, 20 April 2009 (UTC)

Table in "Plasma Transport"

Table lacks an acceptable title or caption. Suggest "Mean distribution of thyroid hormones in the blood plasma of healthy individuals"? — Preceding unsigned comment added by Pikalax (talk • contribs) 21:48, 11 May 2012 (UTC)

Order or article

Surely we should start with the physiological functions and production, rather than just rather randomly jumping in with clinical uses? I'll swap them over soon unless anybody objects. Fgf10 (talk) 15:52, 22 January 2013 (UTC)

Scope of WP:PHARM

Creating this section in case somebody has an objection to this. I am also replacing the 2D structural images with SVGs. Also adding the reliable sources for medical articles template on this page as both hormones are used medically. Brenton (contribs · email · talk · uploads) 08:15, 7 July 2014 (UTC)

Image moved here temporarily

The following biochemical image is moved here to Talk, as it lacks a legend, its labels are not mentioned in the text, and when the text addresses the matter of deiodinases, it uses different terms distinct from those appearing in the image labels (the labels IDI, IDII, outer ring, etc. do not appear in the article). Hence, even to a well-educated reader, reading the text and image in the context of one another is confusing. On return of the image to the article, please rectify the issues with regard to stand-alone understandability, and also create a <ref>...</ref> entry citing the source of the information that the image represents (since in honest academic work—see [1]—at Wikipedia or otherwise, use of images is not supposed to be a means to circumvent having to give attribution/recognition of sources of information. Cheers. Le Prof. — Preceding unsigned comment added by Leprof 7272 (talk • contribs) 22:55, 12 April 2016 (UTC)

Requested move 21 August 2016

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review. No further edits should be made to this section.

The result of the move request was: Moved. (non-admin closure) Omni Flames (talk) 12:11, 28 August 2016 (UTC)

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Thyroid hormone → Thyroid hormones – Two hormones (T3 and T4) are referred to as the thyroid hormones, and this even features in the lead of the article. It would make sense to move this article to a more logical title. Tom (LT) (talk) 02:21, 21 August 2016 (UTC)

• Comment. The relevant guideline is WP:PLURAL, but I am not sure if Thyroid hormone(s) should follow the rule or the exception. --HyperGaruda (talk) 09:02, 21 August 2016 (UTC)
• Support. See e.g. the RM at Talk:Hepatic veins. Specifically, WP:PLURALS addresses multiple distinct instances of related items can be sensibly given a plural title when the alternative would be to create an inappropriately large number of short articles, one on each instance. No such user (talk) 11:38, 24 August 2016 (UTC)

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The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page or in a move review. No further edits should be made to this section.

Impact on coagulation

doi:10.1111/jth.13970 JFW | T@lk 13:13, 11 April 2018 (UTC)

Move extensive chemical names

With this edit, I remove the following line from the lead, since I felt it was cluttery and was not useful for readability.

[o-(4-Hydroxy-3,5-iodophenyl)3,5-diiodophenyl tyrosine] and [o-(4-Hydroxy-3,5-diiodophenyl)3,5diiodophenyl tyrosine]

Feel free to put it back at a more suitable place, if it is necessary to keep them in the article. --Treetear (talk) 12:20, 22 May 2018 (UTC)

A Commons file used on this page has been nominated for deletion

The following Wikimedia Commons file used on this page has been nominated for deletion:

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Participate in the deletion discussion at the nomination page. —Community Tech bot (talk) 21:07, 2 September 2018 (UTC)

Self referential links

thyroxine redirects to this page. at the same time there are links to thyroxine (meaning the substance that is actually named that) in this article. i think the redirection from thyroxine to thyroid hormones should be changed to a deep link to the appropriate section or its own article.

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Hello! This is to let editors know that File:Thyroid hormone synthesis.png, a featured picture used in this article, has been selected as the English Wikipedia's picture of the day (POTD) for May 26, 2023. A preview of the POTD is displayed below and can be edited at Template:POTD/2023-05-26. For the greater benefit of readers, any potential improvements or maintenance that could benefit the quality of this article should be done before its scheduled appearance on the Main Page. If you have any concerns, please place a message at Wikipedia talk:Picture of the day. Thank you!  — Amakuru (talk) 15:52, 20 May 2023 (UTC)

Thyroid hormones are hormones produced and released by the thyroid gland, namely triiodothyronine (T₃) and thyroxine (T₄). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T₃ and T₄ are partially composed of iodine, derived from food. A deficiency of iodine leads to decreased production of T₃ and T₄, enlarges the thyroid tissue and will cause the disease known as simple goitre. This illustration shows the synthesis of thyroid hormones, as seen on an individual thyroid follicular cell.

Illustration credit: Mikael Häggström

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Thank you Amakuru, I am very honored to be on POTD! Mikael Häggström (talk) 02:43, 23 May 2023 (UTC)

Thyroid hormones or Thyroid hormone? (singluar)

My recently acquired (and imperfect) knowledge tells me that T3 is a hormone and T4 is a prohormone. T4 binds weakly at the receptor. The body's strategy is to pump out the relatively inactive T4 from the thyroid, and then convert T4 to T3 where the hormone is needed. If this scenario is true, the article might be relabeled as thyroid hormone (singular).

Furthermore, the article would need to be "reconciled" with an existing article on T3, levothyroxine. Otherwise we have to maintain two articles. Of course, we maintain lots of somewhat parallel articles often, but this case is perhaps more critical since this hormone, both natural and synthetic, is so widely used (7% of US population according to my source). So we want a one-stop shopping site that is closely managed.--Smokefoot (talk) 18:57, 21 May 2023 (UTC)

Either works for me. Mikael Häggström (talk) 02:48, 23 May 2023 (UTC)

Merge proposal

I propose to merge levothyroxine into Thyroid hormones (or preferably Thyroid hormone (see discussion above). The logic:

1. Levothyroxine is T3.
2. T3 is the focus of Thyroid hormones and levothyroxine.
3. As one of the top prescribed drugs (#2 in the US according to my sources), we cannot mess around with readers, we need one masterpiece on this topic. If the topic were unimportant, we wouldn't care.

--Smokefoot (talk) 18:46, 22 May 2023 (UTC)

I find it reasonable to have one article focusing on thyroid hormone(s) as endogenous hormone(s) and one focusing on the drug. It may be named to better reflect this usage, such as Thyroid hormone (drug). Mikael Häggström (talk) 02:48, 23 May 2023 (UTC)