Talk:Rifalazil

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Latest comment: 12 years ago1 comment1 person in discussion

Rifleman 82 (talk) 03:57, 17 December 2012 (UTC)Reply

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C₉H₂₃NO₆P₂ C₄H₄O₃ C₅₁C₆₄N₄O₁₃ C₄H₆BrClO → C₆₀H₇₉N₅O₂₃P₂^[1]

This reaction exhibits the creation of the molecule ryfamicin VIII. Ryfamicin is the original molecule of which rifalazil is the derivative. The purpose of this reaction is to use rifalazil to make a different derivative of the molecule so the substance can be delivered to osseous tissue in the body. This allows the medication to be released at different points in time to the rest of the body in through the blood stream as opposed to all at once.

References

^ Reddy, Ranga; Dietrich, Evelyne; Lafontaine, Yanick; Houghton, Tom J.; Belanger, Odette; Dubois, Anik; Arhin, Francis F.; Sarmiento, Ingrid; Fadhil, Ibtihal (2008). "Bisphosphonated Benzoxazinorifamycin Prodrugs for the Prevention and Treatment of Osteomyelitis". ChemMedChem. 3 (12): 1863–8. doi:10.1002/cmdc.200800255. PMID 18973169.1863-8&rft.date=2008&rft_id=info:doi/10.1002/cmdc.200800255&rft_id=info:pmid/18973169&rft.aulast=Reddy&rft.aufirst=Ranga&rft.au=Dietrich, Evelyne&rft.au=Lafontaine, Yanick&rft.au=Houghton, Tom J.&rft.au=Belanger, Odette&rft.au=Dubois, Anik&rft.au=Arhin, Francis F.&rft.au=Sarmiento, Ingrid&rft.au=Fadhil, Ibtihal&rfr_id=info:sid/en.wikipedia.org:Talk:Rifalazil" class="Z3988">

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[1] Reddy, Ranga; Dietrich, Evelyne; Lafontaine, Yanick; Houghton, Tom J.; Belanger, Odette; Dubois, Anik; Arhin, Francis F.; Sarmiento, Ingrid; Fadhil, Ibtihal (2008). "Bisphosphonated Benzoxazinorifamycin Prodrugs for the Prevention and Treatment of Osteomyelitis". ChemMedChem. 3 (12): 1863–8. doi:10.1002/cmdc.200800255. PMID 18973169.1863-8&rft.date=2008&rft_id=info:doi/10.1002/cmdc.200800255&rft_id=info:pmid/18973169&rft.aulast=Reddy&rft.aufirst=Ranga&rft.au=Dietrich, Evelyne&rft.au=Lafontaine, Yanick&rft.au=Houghton, Tom J.&rft.au=Belanger, Odette&rft.au=Dubois, Anik&rft.au=Arhin, Francis F.&rft.au=Sarmiento, Ingrid&rft.au=Fadhil, Ibtihal&rfr_id=info:sid/en.wikipedia.org:Talk:Rifalazil" class="Z3988">

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