Tumor necrosis factor receptor superfamily, member 19 , also known as TNFRSF19 TROY gene .[ 5]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase -independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.[ 5]
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
