SPRED3

SPRED3
Identifiers
Aliases	SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs	OMIM: 609293; MGI: 2142186; HomoloGene: 28061; GeneCards: SPRED3; OMA:SPRED3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,399,587 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,869,836 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; lateral nuclear group of thalamus; ; vena cava; ; external globus pallidus; ; right ventricle; ; pars reticulata; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; Pons; ; subthalamic nucleus;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; tail of embryo; ; spermatid; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; ventricular zone; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding;
Cellular component	membrane;
Biological process	multicellular organism development; regulation of signal transduction; negative regulation of peptidyl-threonine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	399473
	101809
	ENSG00000188766
	ENSMUSG00000037239
	Q2MJR0
	Q6P6N5
	NM_001039616; NM_001042522; NM_001394336; NM_001394337; NM_001394338
	NM_182927
	NP_001035987
	NP_891557
	Wikidata
View/Edit Human	View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.^[5]

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188766 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037239 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: sprouty-related".
^ Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi:10.1074/jbc.M405189200. PMID 15465815.52543-51&rft.date=2004-12&rft_id=info:doi/10.1074/jbc.M405189200&rft_id=info:pmid/15465815&rft.aulast=Nonami&rft.aufirst=A&rft.au=Kato, R&rft.au=Taniguchi, K&rft.au=Yoshiga, D&rft.au=Taketomi, T&rft.au=Fukuyama, S&rft.au=Harada, M&rft.au=Sasaki, A&rft.au=Yoshimura, A&rft_id=https://doi.org/10.1074%2Fjbc.M405189200&rfr_id=info:sid/en.wikipedia.org:SPRED3" class="Z3988">

Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.767-72&rft.date=2003-03&rft_id=info:doi/10.1016/S0006-291X(03)00259-6&rft_id=info:pmid/12646235&rft.aulast=Kato&rft.aufirst=R&rft.au=Nonami, A&rft.au=Taketomi, T&rft.au=Wakioka, T&rft.au=Kuroiwa, A&rft.au=Matsuda, Y&rft.au=Yoshimura, A&rfr_id=info:sid/en.wikipedia.org:SPRED3" class="Z3988">
Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. doi:10.1007/s10048-003-0164-x. PMID 14618415. S2CID 35025882.81-2&rft.date=2004-02&rft_id=https://api.semanticscholar.org/CorpusID:35025882#id-name=S2CID&rft_id=info:pmid/14618415&rft_id=info:doi/10.1007/s10048-003-0164-x&rft.aulast=Mizoguchi&rft.aufirst=M&rft.au=Nutt, CL&rft.au=Louis, DN&rfr_id=info:sid/en.wikipedia.org:SPRED3" class="Z3988">
King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. doi:10.1016/j.jhep.2005.10.031. PMID 16478641.758-67&rft.date=2006-04&rft_id=info:doi/10.1016/j.jhep.2005.10.031&rft_id=info:pmid/16478641&rft.aulast=King&rft.aufirst=JA&rft.au=Corcoran, NM&rft.au=D'Abaco, GM&rft.au=Straffon, AF&rft.au=Smith, CT&rft.au=Poon, CL&rft.au=Buchert, M&rft.au=I, S&rft.au=Hall, NE&rft.au=Lock, P&rft.au=Hovens, CM&rft_id=https://doi.org/10.1016%2Fj.jhep.2005.10.031&rfr_id=info:sid/en.wikipedia.org:SPRED3" class="Z3988">
Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.1018-23&rft.date=2006-12&rft_id=info:doi/10.1016/j.bbrc.2006.10.150&rft_id=info:pmid/17094949&rft.aulast=Lock&rft.aufirst=P&rft.au=I, ST&rft.au=Straffon, AF&rft.au=Schieb, H&rft.au=Hovens, CM&rft.au=Stylli, SS&rfr_id=info:sid/en.wikipedia.org:SPRED3" class="Z3988">

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188766 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037239 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: sprouty-related".

[pmid15465815-6] Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi:10.1074/jbc.M405189200. PMID 15465815.52543-51&rft.date=2004-12&rft_id=info:doi/10.1074/jbc.M405189200&rft_id=info:pmid/15465815&rft.aulast=Nonami&rft.aufirst=A&rft.au=Kato, R&rft.au=Taniguchi, K&rft.au=Yoshiga, D&rft.au=Taketomi, T&rft.au=Fukuyama, S&rft.au=Harada, M&rft.au=Sasaki, A&rft.au=Yoshimura, A&rft_id=https://doi.org/10.1074%2Fjbc.M405189200&rfr_id=info:sid/en.wikipedia.org:SPRED3" class="Z3988">

[5]

[1]

[2]

[3]

[4]

[6]

SPRED3

References

Further reading