SLAMF6

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

SLAMF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IF7
Identifiers
Aliases	SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6
External IDs	OMIM: 606446; MGI: 1353620; HomoloGene: 49945; GeneCards: SLAMF6; OMA:SLAMF6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.2-q23.3 Start 160,485,030 bp End 160,523,262 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 79.54 cM Start 171,745,082 bp End 171,780,737 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node spleen appendix blood bone marrow cells superficial temporal artery gallbladder mucosa of transverse colon rectum Top expressed in thymus spleen lymph node blood mesenteric lymph nodes gastrula granulocyte submandibular gland subcutaneous adipose tissue embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane Biological process natural killer cell proliferation immune system process positive regulation of interferon-gamma production positive regulation of interleukin-17 production innate immune response positive regulation of natural killer cell mediated cytotoxicity adaptive immune response T-helper 17 cell lineage commitment regulation of immune response natural killer cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114836 30925 Ensembl ENSG00000162739 ENSMUSG00000015314 UniProt Q96DU3 Q9ET39 RefSeq (mRNA) NM_052931 NM_001184714 NM_001184715 NM_001184716 NM_030710 NM_001347186 NM_001347187 RefSeq (protein) NP_001171643 NP_001171644 NP_001171645 NP_443163 NP_001334115 NP_001334116 NP_109635 Location (UCSC) Chr 1: 160.49 – 160.52 Mb Chr 1: 171.75 – 171.78 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Further reading

• Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC". Front. Biosci. 13 (13): 956–65. doi:10.2741/2735. PMID 17981603.
• Hercend T, Meuer S, Brennan A, et al. (1984). "Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure". Cell. Immunol. 86 (2): 381–92. doi:10.1016/0008-8749(84)90393-9. PMID 6610481.
• Kong G, Dalton M, Wardenburg JB, et al. (1996). "Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function". Mol. Cell. Biol. 16 (9): 5026–35. doi:10.1128/MCB.16.9.5026. PMC 231504. PMID 8756661.
• Lee YJ, Luisiri P, Clark MR (1996). "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation". J. Immunol. 157 (9): 3828–37. doi:10.4049/jimmunol.157.9.3828. PMID 8892612.
• Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
• Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Valdez PA, Wang H, Seshasayee D, et al. (2004). "NTB-A, a new activating receptor in T cells that regulates autoimmune disease". J. Biol. Chem. 279 (18): 18662–9. doi:10.1074/jbc.M312313200. PMID 14988414.
• Flaig RM, Stark S, Watzl C (2004). "Cutting edge: NTB-A activates NK cells via homophilic interaction". J. Immunol. 172 (11): 6524–7. doi:10.4049/jimmunol.172.11.6524. PMID 15153464. S2CID 38642218.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stark S, Watzl C (2006). "2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells". Int. Immunol. 18 (2): 241–7. doi:10.1093/intimm/dxh358. PMID 16410313.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells". J. Immunol. 177 (5): 3170–7. doi:10.4049/jimmunol.177.5.3170. PMID 16920955.
• Cao E, Ramagopal UA, Fedorov A, et al. (2006). "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family". Immunity. 25 (4): 559–70. doi:10.1016/j.immuni.2006.06.020. PMID 17045824.
• Banerjee P, Feuer G, Barker E (2007). "Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4 T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells". J. Virol. 81 (18): 9707–17. doi:10.1128/JVI.00887-07. PMC 2045425. PMID 17609265.