SB 203580

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity. SB-203580 was recently assigned the INN Adezamapimod, and is currently in phase 2 clinical trials to prevent post-operative tissue adhesion.

SB 203580

Names
Preferred IUPAC name 4-{4-(4-Fluorophenyl)-2-[4-(methanesulfinyl)phenyl]-1H-imidazol-5-yl}pyridine
Other names RWJ-64809;
Identifiers
CAS Number	152121-47-6 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:90705
ChEMBL	ChEMBL10 Y
ChemSpider	153453 Y
ECHA InfoCard	100.214.849
EC Number	688-252-3
IUPHAR/BPS	5269
PubChem CID	176155
UNII	OU13V1EYWQ Y
CompTox Dashboard (EPA)	DTXSID2040577
InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) N Key: CDMGBJANTYXAIV-UHFFFAOYSA-N N InChI=1/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) Key: CDMGBJANTYXAIV-UHFFFAOYAY
SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Properties
Chemical formula	C21H16FN3OS
Molar mass	377.43 g/mol
Appearance	White to off-white solid
Solubility in DMSO	50 mg/mL
Hazards
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H302, H318
Precautionary statements	P264, P270, P280, P301 P312, P305 P351 P338, P310, P330, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references