60S ribosomal protein L6

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.

RPL6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4D67, 4D5Y, 4UJE
Identifiers
Aliases	RPL6, L6, SHUJUN-2, TAXREB107, TXREB1, ribosomal protein L6
External IDs	OMIM: 603703; MGI: 3647789; HomoloGene: 31001; GeneCards: RPL6; OMA:RPL6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.13 Start 112,405,189 bp End 112,418,838 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad islet of Langerhans Pituitary Gland Achilles tendon lymph node left ovary smooth muscle tissue monocyte n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding structural constituent of ribosome cadherin binding RNA binding Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit nucleus cytoplasm endoplasmic reticulum rough endoplasmic reticulum postsynaptic density polysomal ribosome synapse Biological process cytoplasmic translation regulation of transcription, DNA-templated protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit assembly translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6128 432502 Ensembl ENSG00000089009 n/a UniProt Q02878 n/a RefSeq (mRNA) NM_000970 NM_001024662 NM_001320137 NM_001320138 NM_001320139 NM_001320140 NM_001320141 NM_001320142 XM_036156129 RefSeq (protein) NP_000961 NP_001019833 NP_001307066 NP_001307067 NP_001307068 NP_001307069 NP_001307070 NP_001307071 n/a Location (UCSC) Chr 12: 112.41 – 112.42 Mb n/a PubMed search
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

RPL6 has been shown to interact with Basic fibroblast growth factor.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Nika H, Hultin T (1984). "Location of the sulfhydryl groups involved in disulfide interaction between the neighboring proteins L6 and L29 in mammalian ribosomes. S-cleavage of the cyanylated proteins in polyacrylamide gels after separation by dodecylsulfate gel electrophoresis". Eur. J. Biochem. 142 (3): 521–6. doi:10.1111/j.1432-1033.1984.tb08316.x. PMID 6468376.
• Todokoro K, Ulbrich N, Chan YL, Wool IG (1981). "Characterization of the binding of rat liver ribosomal proteins L6, L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid". J. Biol. Chem. 256 (14): 7207–12. doi:10.1016/S0021-9258(19)68949-0. PMID 7251593.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Ohta K, Endo T, Gunji K, Onaya T (1994). "Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues". J. Mol. Endocrinol. 12 (1): 85–92. doi:10.1677/jme.0.0120085. PMID 8185817.
• Monk S, Sakuntabhai A, Carter SA, et al. (1998). "Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region". Am. J. Hum. Genet. 62 (4): 890–903. doi:10.1086/301794. PMC 1377034. PMID 9529352.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Shen B, Arese M, Gualandris A, Rifkin DB (1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochem. Biophys. Res. Commun. 252 (2): 524–8. doi:10.1006/bbrc.1998.9677. PMID 9826564.
• Ye Z, Connor JR (2000). "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs". Biochem. Biophys. Res. Commun. 275 (1): 223–7. doi:10.1006/bbrc.2000.3282. PMID 10944468.
• Kenmochi N, Yoshihama M, Higa S, Tanaka T (2000). "The human ribosomal protein L6 gene in a critical region for Noonan syndrome". J. Hum. Genet. 45 (5): 290–3. doi:10.1007/s100380070018. PMID 11043511.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Du JP, Jin XH, Shi YQ, et al. (2003). "[Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance]". Zhonghua Zhong Liu Za Zhi. 25 (1): 21–5. PMID 12678981.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.