POU3F1

POU domain, class 3, transcription factor 1 (also known as Oct-6) is a protein that in humans is encoded by the POU3F1 gene.

POU3F1
Identifiers
Aliases	POU3F1, OCT6, OTF6, SCIP, POU class 3 homeobox 1
External IDs	OMIM: 602479; MGI: 101896; HomoloGene: 135923; GeneCards: POU3F1; OMA:POU3F1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 38,043,829 bp End 38,046,793 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 57.86 cM Start 124,550,600 bp End 124,554,448 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen tibial nerve skin of leg gonad skin of arm Region I of hippocampus proper gums caudate nucleus sural nerve putamen Top expressed in Region I of hippocampus proper barrel cortex skin of external ear dorsal striatum ganglionic eminence female urethra medial ganglionic eminence hair follicle nucleus accumbens hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription coactivator activity DNA binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus nucleoplasm Biological process axon ensheathment regulation of transcription by RNA polymerase II myelination forebrain development Schwann cell development brain development regulation of transcription, DNA-templated transcription, DNA-templated myelination in peripheral nervous system keratinocyte differentiation positive regulation of transcription by RNA polymerase II epidermis development positive regulation of transcription, DNA-templated positive regulation of gene expression transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5453 18991 Ensembl ENSG00000185668 ENSMUSG00000090125 UniProt Q03052 P21952 RefSeq (mRNA) NM_002699 NM_011141 RefSeq (protein) NP_002690 NP_035271 Location (UCSC) Chr 1: 38.04 – 38.05 Mb Chr 4: 124.55 – 124.55 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Octamer transcription factor

Further reading

• Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G (Sep 1990). "Expression and activity of the POU transcription factor SCIP". Science. 249 (4974): 1300–3. Bibcode:1990Sci...249.1300M. doi:10.1126/science.1975954. PMID 1975954.
• Suzuki N, Rohdewohld H, Neuman T, Gruss P, Schöler HR (Nov 1990). "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain". The EMBO Journal. 9 (11): 3723–32. doi:10.1002/j.1460-2075.1990.tb07585.x. PMC 552128. PMID 1976514.
• Zwilling S, König H, Wirth T (Mar 1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors". The EMBO Journal. 14 (6): 1198–208. doi:10.1002/j.1460-2075.1995.tb07103.x. PMC 398197. PMID 7720710.
• Leger H, Sock E, Renner K, Grummt F, Wegner M (Jul 1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y". Molecular and Cellular Biology. 15 (7): 3738–47. doi:10.1128/mcb.15.7.3738. PMC 230612. PMID 7791781.
• Faus I, Hsu HJ, Fuchs E (May 1994). "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia". Molecular and Cellular Biology. 14 (5): 3263–75. doi:10.1128/mcb.14.5.3263. PMC 358693. PMID 7909356.
• Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (Oct 1995). "Expression of transcription regulating genes in human preimplantation embryos". Human Reproduction. 10 (10): 2787–92. doi:10.1093/oxfordjournals.humrep.a135792. PMID 8567814.
• Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P, Grosveld F, Meijer D (Jul 1996). "The POU factor Oct-6 and Schwann cell differentiation". Science. 273 (5274): 507–10. Bibcode:1996Sci...273..507J. doi:10.1126/science.273.5274.507. PMID 8662541. S2CID 39349653.
• Sock E, Enderich J, Rosenfeld MG, Wegner M (Jul 1996). "Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6". The Journal of Biological Chemistry. 271 (29): 17512–8. doi:10.1074/jbc.271.29.17512. PMID 8663425.
• Malik KF, Jaffe H, Brady J, Young WS (Apr 1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U". Brain Research. Molecular Brain Research. 45 (1): 99–107. doi:10.1016/S0169-328X(96)00238-0. PMID 9105675.
• Sumiyama K, Washio-Watanabe K, Ono T, Yoshida MC, Hayakawa T, Ueda S (Feb 1998). "Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2". Mammalian Genome. 9 (2): 180–1. doi:10.1007/s003359900721. PMID 9457692. S2CID 9495282.
• Arroyo EJ, Bermingham JR, Rosenfeld MG, Scherer SS (Oct 1998). "Promyelinating Schwann cells express Tst-1/SCIP/Oct-6". The Journal of Neuroscience. 18 (19): 7891–902. doi:10.1523/JNEUROSCI.18-19-07891.1998. PMC 6792991. PMID 9742157.
• Kawasaki T, Oka N, Tachibana H, Akiguchi I, Shibasaki H (Mar 2003). "Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies". Acta Neuropathologica. 105 (3): 203–8. doi:10.1007/s00401-002-0630-9. hdl:2433/148771. PMID 12557005. S2CID 2340303.
• Beck IM, Müller M, Mentlein R, Sadowski T, Mueller MS, Paus R, Sedlacek R (May 2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". The Journal of Investigative Dermatology. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.
• Ryu EJ, Wang JY, Le N, Baloh RH, Gustin JA, Schmidt RE, Milbrandt J (Oct 2007). "Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss". The Journal of Neuroscience. 27 (43): 11552–9. doi:10.1523/JNEUROSCI.5497-06.2007. PMC 6673231. PMID 17959798.

External links

• POU3F1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.