Solute carrier organic anion transporter family member 1B1

SLCO1B1
Identifiers
Aliases	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6, solute carrier organic anion transporter family member 1B1
External IDs	OMIM: 604843; MGI: 1351899; HomoloGene: 74575; GeneCards: SLCO1B1; OMA:SLCO1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,239,796 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	141,632,372 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; buccal mucosa cell; ; pancreatic ductal cell; ; gallbladder; ; renal cortex; ; cervix; ; canal of the cervix; ; mouth; ; haematopoietic system;
	Top expressed in
	left lobe of liver; ; embryo; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; primary visual cortex; ; proximal tubule; ; jejunum; ; thoracic diaphragm; ; pancreas; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; sodium-independent organic anion transmembrane transporter activity; thyroid hormone transmembrane transporter activity; bile acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; bile acid and bile salt transport; organic anion transport; thyroid hormone transport; sodium-independent organic anion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10599
	28253
	ENSG00000134538
	ENSMUSG00000030236
	Q9Y6L6
	Q9JJL3
	NM_006446
	NM_020495; NM_178235
	NP_006437
	NP_065241
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.^[5]^[6] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.^[7] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134538 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030236 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H (Jul 1999). "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J Biol Chem. 274 (24): 17159–63. doi:10.1074/jbc.274.24.17159. PMID 10358072.
^ "Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1".
^ Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M (2013). "SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink". Clinical Pharmacology & Therapeutics. 94 (6): 695–701. doi:10.1038/clpt.2013.161. PMC 3831180. PMID 23942138.
^ Huser V, Cimino JJ (2013). "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input". AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science. 2013: 81. PMID 24303303.

Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG (2000). "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters". J. Biol. Chem. 274 (52): 37161–8. doi:10.1074/jbc.274.52.37161. PMID 10601278.
König J, Cui Y, Nies AT, Keppler D (2000). "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G156–64. doi:10.1152/ajpgi.2000.278.1.G156. PMID 10644574. S2CID 7358020.
Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss EH, Zwierzina H (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. doi:10.4049/jimmunol.164.6.3169. PMID 10706707.
König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
Cui Y, König J, Leier I, Buchholz U, Keppler D (2001). "Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6". J. Biol. Chem. 276 (13): 9626–30. doi:10.1074/jbc.M004968200. PMID 11134001.
Tirona RG, Leake BF, Merino G, Kim RB (2001). "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans". J. Biol. Chem. 276 (38): 35669–75. doi:10.1074/jbc.M103792200. PMID 11477075.
Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ, Kullak-Ublick GA (2001). "Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha". J. Biol. Chem. 276 (40): 37206–14. doi:10.1074/jbc.M103988200. PMID 11483603.
Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. doi:10.1124/jpet.302.2.804. PMID 12130747.
Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J (2003). "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter". J. Biol. Chem. 277 (45): 43058–63. doi:10.1074/jbc.M207735200. PMID 12196548.
Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003). "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation". J. Pharmacol. Exp. Ther. 304 (1): 223–8. doi:10.1124/jpet.102.043026. PMID 12490595. S2CID 1475068.
Wang P, Kim RB, Chowdhury JR, Wolkoff AW (2003). "The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695–9. doi:10.1074/jbc.M301100200. PMID 12670950.
Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365. S2CID 6570648.
Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics. 14 (7): 429–40. doi:10.1097/01.fpc.0000114750.08559.32. PMID 15226675.
Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS (2005). "Risk factors for severe hyperbilirubinemia in neonates". Pediatr. Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464.
Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia". Chem. Biol. Interact. 150 (2): 179–87. doi:10.1016/j.cbi.2004.08.008. PMID 15535988.
Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS (2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenet. Genomics. 15 (1): 43–50. doi:10.1097/01213011-200501000-00007. PMID 15864125. S2CID 24247125.
Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T, Leake B, Wang Q, Han L, Wang PG, Edeki T, Sahelijo L, Doan T, Allen A, Spear BB, Kim RB (2006). "Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics". Clin. Pharmacol. Ther. 79 (3): 186–96. doi:10.1016/j.clpt.2005.11.003. PMID 16513443. S2CID 21496707.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134538 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030236 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10358072-5] Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H (Jul 1999). "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J Biol Chem. 274 (24): 17159–63. doi:10.1074/jbc.274.24.17159. PMID 10358072.

[entrez-6] "Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1".

[art1-7] Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M (2013). "SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink". Clinical Pharmacology & Therapeutics. 94 (6): 695–701. doi:10.1038/clpt.2013.161. PMC 3831180. PMID 23942138.

[art2-8] Huser V, Cimino JJ (2013). "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input". AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science. 2013: 81. PMID 24303303.

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

Solute carrier organic anion transporter family member 1B1

See also

References

Further reading