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Mangione is a surname. Notable people with the surname include:
- Chuck Mangione (born 1940), American flugelhorn player, trumpeter and composer
- Francesco Mangione (born 1957), Italian-born Australian, convicted of the murder of his 26-year-old cousin in 2002
- Gap Mangione (born 1938), jazz pianist, composer, arranger, and bandleader from Rochester, New York, United States
- Jerre Mangione (1909–1998), American writer and scholar of the Sicilian-American experience
- Mike Mangione, American singer-songwriter, guitarist and percussionist
- Salvatore Mangione, known as Salvo (1947–2015), Italian artist who lived and worked in Turin
- Stéphane Mangione (born 1979), French football player