MAF (gene)

Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in humans is encoded by the MAF gene.

MAF
Identifiers
Aliases	MAF, CCA4, c-AYGRP, CTRCT21, MAF bZIP transcription factor
External IDs	OMIM: 177075; MGI: 96909; HomoloGene: 74552; GeneCards: MAF; OMA:MAF - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q23.2 Start 79,585,843 bp End 79,600,737 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 E1|8 62.61 cM Start 116,409,681 bp End 116,434,533 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa germinal epithelium gums gingival epithelium trigeminal ganglion skin of hip parietal pleura human penis periodontal fiber vulva Top expressed in stroma of bone marrow skin of external ear molar umbilical cord epithelium of lens left lung lobe body of femur migratory enteric neural crest cell mesenteric lymph nodes human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component cytoplasm chromatin nucleus Biological process inner ear development cytokine production regulation of chondrocyte differentiation positive regulation of gene expression lens development in camera-type eye lens fiber cell differentiation negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated cell development transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4094 17132 Ensembl ENSG00000178573 ENSMUSG00000055435 UniProt O75444 P54843 RefSeq (mRNA) NM_001031804 NM_005360 NM_001025577 RefSeq (protein) NP_001026974 NP_005351 NP_001020748 Location (UCSC) Chr 16: 79.59 – 79.6 Mb Chr 8: 116.41 – 116.43 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Types

One type, MafA, also known as RIPE3b1, promotes pancreatic development, as well as insulin gene transcription.

Interactions

MAF has been shown to interact with:

• CREBBP
• EP300
• MYB
• SOX9.

Further reading

• Kerppola TK, Curran T (Mar 1994). "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun". Oncogene. 9 (3): 675–84. PMID 8108109.
• Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.
• Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology. 18 (5): 2729–37. doi:10.1128/MCB.18.5.2729. PMC 110652. PMID 9566892.
• Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried T, Kuehl WM (Jun 1998). "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma". Blood. 91 (12): 4457–63. doi:10.1182/blood.V91.12.4457. PMID 9616139. S2CID 14835515.
• Christodoulopoulos P, Cameron L, Nakamura Y, Lemière C, Muro S, Dugas M, Boulet LP, Laviolette M, Olivenstein R, Hamid Q (Apr 2001). "TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression". The Journal of Allergy and Clinical Immunology. 107 (4): 586–91. doi:10.1067/mai.2001.114883. PMID 11295643.
• Jamieson RV, Perveen R, Kerr B, Carette M, Yardley J, Heon E, Wirth MG, van Heyningen V, Donnai D, Munier F, Black GC (Jan 2002). "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma". Human Molecular Genetics. 11 (1): 33–42. doi:10.1093/hmg/11.1.33. PMID 11772997.
• Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
• Dhakshinamoorthy S, Jaiswal AK (Aug 2002). "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction". Oncogene. 21 (34): 5301–12. doi:10.1038/sj.onc.1205642. PMID 12149651.
• Cousins DJ, Lee TH, Staynov DZ (Sep 2002). "Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines". Journal of Immunology. 169 (5): 2498–506. doi:10.4049/jimmunol.169.5.2498. PMID 12193719.
• Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733.
• DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG (Jun 2003). "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice". Molecular Vision. 9: 288–94. PMID 12835653.
• Grimbert P, Valanciute A, Audard V, Pawlak A, Le gouvelo S, Lang P, Niaudet P, Bensman A, Guellaën G, Sahali D (Sep 2003). "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization". The Journal of Experimental Medicine. 198 (5): 797–807. doi:10.1084/jem.20030566. PMC 1865475. PMID 12939343.
• Valanciuté A, le Gouvello S, Solhonne B, Pawlak A, Grimbert P, Lyonnet L, Hue S, Lang P, Remy P, Salomon R, Bensman A, Guellaën G, Sahali D (Jan 2004). "NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome". Journal of Immunology. 172 (1): 688–98. doi:10.4049/jimmunol.172.1.688. PMID 14688382.
• Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE (Oct 2003). "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance". Leukemia & Lymphoma. 44 (10): 1761–6. doi:10.1080/1042819031000111035. PMID 14692531. S2CID 3191366.
• Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM (Feb 2004). "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma". Cancer Cell. 5 (2): 191–9. doi:10.1016/S1535-6108(04)00019-4. PMID 14998494.
• Cao S, Liu J, Song L, Ma X (Mar 2005). "The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages". Journal of Immunology. 174 (6): 3484–92. doi:10.4049/jimmunol.174.6.3484. PMC 2955976. PMID 15749884.
• Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, Yamada A, Maeda A, Matsuno F, Hata H, Suzuki A, Imagawa S, Mitsuya H, Esumi H, Koyama A, Yamamoto M, Mori N, Takahashi S (Jan 2006). "Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human". Cancer Research. 66 (2): 812–9. doi:10.1158/0008-5472.CAN-05-2154. PMID 16424013.
• Vanita V, Singh D, Robinson PN, Sperling K, Singh JR (Mar 2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family". American Journal of Medical Genetics Part A. 140 (6): 558–66. doi:10.1002/ajmg.a.31126. PMID 16470690. S2CID 13734492.

External links

• MAF protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.