KCNJ3

G protein-activated inward rectifier potassium channel 1 (GIRK-1) is encoded in the human by the gene KCNJ3.

KCNJ3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N9P, 1U4E, 2QKS, 3K6N
Identifiers
Aliases	KCNJ3, GIRK1, KGA, KIR3.1, potassium voltage-gated channel subfamily J member 3, potassium inwardly rectifying channel subfamily J member 3
External IDs	OMIM: 601534; MGI: 104742; HomoloGene: 1687; GeneCards: KCNJ3; OMA:KCNJ3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.1 Start 154,697,855 bp End 154,858,354 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.1 Start 55,435,970 bp End 55,598,145 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus cerebellar cortex cerebellar hemisphere cerebellar vermis postcentral gyrus right hemisphere of cerebellum primary visual cortex superior frontal gyrus Top expressed in lobe of cerebellum lateral geniculate nucleus dentate gyrus of hippocampal formation granule cell cerebellar vermis superior frontal gyrus subiculum medial geniculate nucleus medial dorsal nucleus atrium lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein activated inward rectifier potassium channel activity protein binding inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Cellular component integral component of membrane T-tubule cell surface plasma membrane membrane external side of plasma membrane voltage-gated potassium channel complex parallel fiber to Purkinje cell synapse integral component of presynaptic membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport response to electrical stimulus regulation of heart rate by cardiac conduction membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential ventricular cardiac muscle cell membrane repolarization potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3760 16519 Ensembl ENSG00000162989 ENSMUSG00000026824 UniProt P48549 P63250 RefSeq (mRNA) NM_002239 NM_001260508 NM_001260509 NM_001260510 NM_008426 NM_001304810 NM_001355118 RefSeq (protein) NP_001247437 NP_001247438 NP_001247439 NP_002230 NP_001291739 NP_032452 NP_001342047 Location (UCSC) Chr 2: 154.7 – 154.86 Mb Chr 2: 55.44 – 55.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.

Interactions

KCNJ3 has been shown to interact with KCNJ5.

See also

• G protein-coupled inwardly-rectifying potassium channel
• Inward-rectifier potassium ion channel

Further reading

• Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
• Stoffel M, Espinosa R, Powell KL, et al. (1994). "Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism". Genomics. 21 (1): 254–6. doi:10.1006/geno.1994.1253. PMID 8088798.
• Schoots O, Yue KT, MacDonald JF, et al. (1996). "Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum". Brain Res. Mol. Brain Res. 39 (1–2): 23–30. doi:10.1016/0169-328X(95)00349-W. PMID 8804710.
• Chan KW, Langan MN, Sui JL, et al. (1996). "A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins". J. Gen. Physiol. 107 (3): 381–97. doi:10.1085/jgp.107.3.381. PMC 2216996. PMID 8868049.
• Liao YJ, Jan YN, Jan LY (1996). "Heteromultimerization of G-protein-gated inwardly rectifying K channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain". J. Neurosci. 16 (22): 7137–50. doi:10.1523/JNEUROSCI.16-22-07137.1996. PMC 6578936. PMID 8929423.
• Signorini S, Liao YJ, Duncan SA, et al. (1997). "Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K channel GIRK2". Proc. Natl. Acad. Sci. U.S.A. 94 (3): 923–7. Bibcode:1997PNAS...94..923S. doi:10.1073/pnas.94.3.923. PMC 19615. PMID 9023358.
• Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K channels". FEBS Lett. 405 (3): 291–8. Bibcode:1997FEBSL.405..291H. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307. S2CID 44072628.
• Schoots O, Voskoglou T, Van Tol HH (1997). "Genomic organization and promoter analysis of the human G-protein-coupled K channel Kir3.1 (KCNJ3/HGIRK1)". Genomics. 39 (3): 279–88. doi:10.1006/geno.1996.4495. PMID 9119365.
• Corey S, Clapham DE (1998). "Identification of native atrial G-protein-regulated inwardly rectifying K (GIRK4) channel homomultimers". J. Biol. Chem. 273 (42): 27499–504. doi:10.1074/jbc.273.42.27499. PMID 9765280.
• Kennedy ME, Nemec J, Corey S, et al. (1999). "GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels". J. Biol. Chem. 274 (4): 2571–82. doi:10.1074/jbc.274.4.2571. PMID 9891030.
• Pabon A, Chan KW, Sui JL, et al. (2000). "Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function". J. Biol. Chem. 275 (39): 30677–82. doi:10.1074/jbc.M005338200. PMID 10889209.
• He C, Yan X, Zhang H, et al. (2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K( ) channel activity through interactions with the beta gamma subunits of G proteins". J. Biol. Chem. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.
• Chen L, Kawano T, Bajic S, et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K channels: Implication for Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8430–5. Bibcode:2002PNAS...99.8430C. doi:10.1073/pnas.122682899. PMC 123084. PMID 12034888.
• Lavine N, Ethier N, Oak JN, et al. (2003). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ivanina T, Rishal I, Varon D, et al. (2003). "Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K channel". J. Biol. Chem. 278 (31): 29174–83. doi:10.1074/jbc.M304518200. PMID 12743112.
• Shankar H, Murugappan S, Kim S, et al. (2004). "Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses". Blood. 104 (5): 1335–43. doi:10.1182/blood-2004-01-0069. PMID 15142872.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer. 5: 104. doi:10.1186/1471-2407-5-104. PMC 1208863. PMID 16109170.

External links

• KCNJ3 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.