ILKAP

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.

ILKAP
Identifiers
Aliases	ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD
External IDs	MGI: 1914694; HomoloGene: 31525; GeneCards: ILKAP; OMA:ILKAP - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 238,170,402 bp End 238,203,708 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 91,373,861 bp End 91,398,815 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum granulocyte gastric mucosa muscle layer of sigmoid colon anterior pituitary body of uterus right lobe of thyroid gland left lobe of thyroid gland tibial nerve Top expressed in neural layer of retina ventricular zone neural tube granulocyte epiblast thymus muscle of thigh right kidney lip embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein binding catalytic activity phosphoprotein phosphatase activity hydrolase activity metal ion binding cation binding Cellular component cytoplasm nucleus nucleoplasm cytosol Biological process protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80895 67444 Ensembl ENSG00000132323 ENSMUSG00000026309 UniProt Q9H0C8 Q8R0F6 RefSeq (mRNA) NM_030768 NM_176799 NM_023343 NM_001355152 RefSeq (protein) NP_110395 NP_075832 NP_001342081 Location (UCSC) Chr 2: 238.17 – 238.2 Mb Chr 1: 91.37 – 91.4 Mb PubMed search
Wikidata
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The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.

Further reading

• Tong Y, Quirion R, Shen SH (December 1998). "Cloning and characterization of a novel mammalian PP2C isozyme". The Journal of Biological Chemistry. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
• Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE (April 2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.