Homeobox A10

HOXA10
Identifiers
Aliases	HOXA10, HOX1, HOX1.8, HOX1H, PL, Homeobox A10
External IDs	OMIM: 142957; MGI: 96171; HomoloGene: 7365; GeneCards: HOXA10; OMA:HOXA10 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,180,261 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	52,217,834 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; body of uterus; ; Skeletal muscle tissue of biceps brachii; ; myometrium; ; endometrium; ; vastus lateralis muscle; ; canal of the cervix; ; muscle of leg; ; gastrocnemius muscle; ; glutes;
	Top expressed in
	gastrula; ; decidua; ; wall of uterus; ; stroma of kidney; ; tail of embryo; ; connecting tubule; ; vas deferens; ; genital tubercle; ; Bowman's capsule; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; nucleus;
Biological process	skeletal system development; proximal/distal pattern formation; male gonad development; regulation of transcription, DNA-templated; transcription, DNA-templated; single fertilization; uterus development; multicellular organism development; embryonic limb morphogenesis; spermatogenesis; regulation of gene expression; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3206
	15395
	ENSG00000253293
	ENSMUSG00000000938
	P31260
	P31310
	NM_018951; NM_153715
	NM_001122950; NM_008263
	NP_061824
	NP_001116422; NP_032289
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.^[5]^[6]^[7]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.^[7] Downregulation of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3.^[8]

Interactions

Homeobox A10 has been shown to interact with PTPN6.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000253293 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000938 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
^ ^a ^b "Entrez Gene: HOXA10 homeobox A10".
^ Godbole G, Suman P, Malik A, Galvankar M, Joshi N, Fazleabas A, et al. (August 2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion". Endocrinology. 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMC 6283436. PMID 28520923.
^ Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (September 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–36888. doi:10.1074/jbc.M203917200. PMID 12145285.

Eun Kwon H, Taylor HS (December 2004). "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences. 1034 (1): 1–18. Bibcode:2004NYASA1034....1E. doi:10.1196/annals.1335.001. PMID 15731295. S2CID 41501204.
Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, et al. (June 1991). "A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells". Nucleic Acids Research. 19 (12): 3443–3449. doi:10.1093/nar/19.12.3443. PMC 328346. PMID 1676505.
Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, et al. (November 1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National Academy of Sciences of the United States of America. 86 (21): 8536–8540. Bibcode:1989PNAS...86.8536S. doi:10.1073/pnas.86.21.8536. PMC 298317. PMID 2573064.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, et al. (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–10402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, et al. (December 1994). "Differential expression of homeobox genes in functionally distinct CD34 subpopulations of human bone marrow cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12223–12227. Bibcode:1994PNAS...9112223S. doi:10.1073/pnas.91.25.12223. PMC 45409. PMID 7527557.
Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, et al. (October 1995). "Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental Hematology. 23 (11): 1160–1166. PMID 7556525.
Satokata I, Benson G, Maas R (March 1995). "Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice". Nature. 374 (6521): 460–463. Bibcode:1995Natur.374..460S. doi:10.1038/374460a0. PMID 7700356. S2CID 4337017.
Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M (January 1994). "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype". Biochemical Pharmacology. 47 (1): 137–143. doi:10.1016/0006-2952(94)90447-2. PMID 7906121.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–115. doi:10.1159/000134320. PMID 8646877.
Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, et al. (January 1997). "Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia". Molecular and Cellular Biology. 17 (1): 495–505. doi:10.1128/mcb.17.1.495. PMC 231774. PMID 8972230.
Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, et al. (November 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–6458. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.
Taylor HS, Vanden Heuvel GB, Igarashi P (December 1997). "A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes". Biology of Reproduction. 57 (6): 1338–1345. doi:10.1095/biolreprod57.6.1338. PMID 9408238.
Taylor HS, Arici A, Olive D, Igarashi P (April 1998). "HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium". The Journal of Clinical Investigation. 101 (7): 1379–1384. doi:10.1172/JCI1057. PMC 508715. PMID 9525980.
Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE (May 1999). "Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells". Leukemia. 13 (5): 687–698. doi:10.1038/sj/leu/2401410. PMID 10374871.
Eklund EA, Jalava A, Kakar R (June 2000). "Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines". The Journal of Biological Chemistry. 275 (26): 20117–20126. doi:10.1074/jbc.M907915199. PMID 10766757.
Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, et al. (April 2001). "Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo". Blood. 97 (8): 2286–2292. doi:10.1182/blood.V97.8.2286. PMID 11290589.
Cermik D, Karaca M, Taylor HS (July 2001). "HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract". The Journal of Clinical Endocrinology and Metabolism. 86 (7): 3387–3392. doi:10.1210/jcem.86.7.7675. PMID 11443215. S2CID 23775476.
Shen WF, Krishnan K, Lawrence HJ, Largman C (November 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–7522. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
Godbole G, Modi D (June 2010). "Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells". Journal of Reproductive Immunology. 85 (2): 130–139. doi:10.1016/j.jri.2010.03.003. PMID 20478621.
Godbole GB, Modi DN, Puri CP (September 2007). "Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli". Reproduction. 134 (3): 513–523. doi:10.1530/REP-07-0234. PMID 17709569.

External links

HOXA10 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000253293 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000938 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1973146-5] McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[pmid1358459-6] Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.

[entrez-7] "Entrez Gene: HOXA10 homeobox A10".

[8] Godbole G, Suman P, Malik A, Galvankar M, Joshi N, Fazleabas A, et al. (August 2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion". Endocrinology. 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMC 6283436. PMID 28520923.

[pmid12145285-9] Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (September 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–36888. doi:10.1074/jbc.M203917200. PMID 12145285.

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Homeobox A10

Contents

Function

Interactions

See also

References

Further reading

External links