HEXIM1

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.

HEXIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GD7, 3S9G
Identifiers
Aliases	HEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1
External IDs	OMIM: 607328; MGI: 2385923; HomoloGene: 31382; GeneCards: HEXIM1; OMA:HEXIM1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 45,148,475 bp End 45,152,099 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E1 Start 103,007,057 bp End 103,010,551 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte middle temporal gyrus gingival epithelium germinal epithelium kidney tubule glomerulus Brodmann area 23 placenta metanephric glomerulus amniotic fluid Top expressed in gastrula median eminence adrenal gland transitional epithelium of urinary bladder lateral geniculate nucleus ascending aorta granulocyte medial geniculate nucleus ciliary body central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding snRNA binding 7SK snRNA binding cyclin-dependent protein serine/threonine kinase inhibitor activity Cellular component nucleoplasm cytoplasm nucleus Biological process positive regulation of signal transduction by p53 class mediator heart development regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II activation of innate immune response immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10614 192231 Ensembl ENSG00000186834 ENSMUSG00000048878 UniProt O94992 Q8R409 RefSeq (mRNA) NM_006460 NM_138753 RefSeq (protein) NP_006451 NP_620092 Location (UCSC) Chr 17: 45.15 – 45.15 Mb Chr 11: 103.01 – 103.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HEXIM1 has been shown to interact with Cyclin T1 and Cdk9

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Ohsuzu F, Tanaka H (2003). "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells". Genes Cells. 8 (2): 95–107. doi:10.1046/j.1365-2443.2003.00618.x. PMID 12581153. S2CID 21478049.
• Wittmann BM, Wang N, Montano MM (2003). "Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors". Cancer Res. 63 (16): 5151–8. PMID 12941847.
• Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q (2003). "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA". Mol. Cell. 12 (4): 971–82. doi:10.1016/S1097-2765(03)00388-5. PMID 14580347.
• Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
• Yik JH, Chen R, Pezda AC, Samford CS, Zhou Q (2004). "A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb". Mol. Cell. Biol. 24 (12): 5094–105. doi:10.1128/MCB.24.12.5094-5105.2004. PMC 419863. PMID 15169877.
• Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O (2005). "Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor". EMBO J. 23 (13): 2608–19. doi:10.1038/sj.emboj.7600275. PMC 449783. PMID 15201869.
• Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
• Byers SA, Price JP, Cooper JJ, Li Q, Price DH (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
• Schulte A, Czudnochowski N, Barboric M, Schönichen A, Blazek D, Peterlin BM, Geyer M (2005). "Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat". J. Biol. Chem. 280 (26): 24968–77. doi:10.1074/jbc.M501431200. PMID 15855166.
• Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM (2005). "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1". Oncogene. 24 (36): 5576–88. doi:10.1038/sj.onc.1208728. PMID 18630264.
• Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H (2005). "HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8555–60. Bibcode:2005PNAS..102.8555S. doi:10.1073/pnas.0409863102. PMC 1150813. PMID 18631832.
• Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
• Fraldi A, Varrone F, Napolitano G, Michels AA, Majello B, Bensaude O, Lania L (2006). "Inhibition of Tat activity by the HEXIM1 protein". Retrovirology. 2: 42. doi:10.1186/1742-4690-2-42. PMC 1183248. PMID 15992410.
• Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O (2005). "Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer". J. Biol. Chem. 280 (34): 30619–29. doi:10.1074/jbc.M502471200. PMID 15994294.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.