HBG2

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.

HBG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FDH, 4MQJ, 4MQK
Identifiers
Aliases	HBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2
External IDs	OMIM: 142250; MGI: 96027; HomoloGene: 128032; GeneCards: HBG2; OMA:HBG2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 5,253,188 bp End 5,505,605 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E3|7 54.85 cM Start 103,500,956 bp End 103,502,423 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta ganglionic eminence ventricular zone blood monocyte bone marrow bone marrow cells apex of heart spleen lung Top expressed in external carotid artery internal carotid artery endocardial cushion abdominal wall maxillary prominence mandibular prominence somite hand human fetus yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding oxygen carrier activity heme binding metal ion binding oxygen binding peroxidase activity protein binding haptoglobin binding organic acid binding Cellular component blood microparticle hemoglobin complex cytosol haptoglobin-hemoglobin complex Biological process oxygen transport blood coagulation transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3048 15135 Ensembl ENSG00000196565 ENSMUSG00000052187 UniProt P69892 P02104 RefSeq (mRNA) NM_000184 NM_008221 RefSeq (protein) NP_000175 NP_032247 Location (UCSC) Chr 11: 5.25 – 5.51 Mb Chr 7: 103.5 – 103.5 Mb PubMed search
Wikidata
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Function

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.

Further reading

• Gelinas R, Yagi M, Endlich B, et al. (1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene". Prog. Clin. Biol. Res. 191: 125–39. PMID 2413469.
• Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.

External links

• Overview of all the structural information available in the PDB for UniProt: P69892 (Hemoglobin subunit gamma-2) at the PDBe-KB.