Fractional synthetic rate

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A fractional synthetic rate (FSR) is the rate at which a precursor compound is incorporated into a product per unit of product mass.[1] The metric has been used to estimate the rate at which proteins, lipids, and lipoproteins are synthesized within humans and other animals.[1][2] The formula used to calculate the FSR from a stable isotope tracer experiment is:[1]

References

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  1. ^ a b c Foster DM, Barrett PH, Toffolo G, Beltz WF, Cobelli C (1993). "Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data" (PDF). J. Lipid Res. 34 (12): 2193–2205. doi:10.1016/S0022-2275(20)35360-8. PMID 8301238.2193-2205&rft.date=1993&rft_id=info:doi/10.1016/S0022-2275(20)35360-8&rft_id=info:pmid/8301238&rft.aulast=Foster&rft.aufirst=DM&rft.au=Barrett, PH&rft.au=Toffolo, G&rft.au=Beltz, WF&rft.au=Cobelli, C&rft_id=http://www.jlr.org/content/34/12/2193.full.pdf&rfr_id=info:sid/en.wikipedia.org:Fractional synthetic rate" class="Z3988">
  2. ^ Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ (June 2013). "Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism" (PDF). J. Physiol. 591 (11): 2911–2923. doi:10.1113/jphysiol.2013.253203. PMC 3690694. PMID 23551944.2911-2923&rft.date=2013-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690694#id-name=PMC&rft_id=info:pmid/23551944&rft_id=info:doi/10.1113/jphysiol.2013.253203&rft.aulast=Wilkinson&rft.aufirst=DJ&rft.au=Hossain, T&rft.au=Hill, DS&rft.au=Phillips, BE&rft.au=Crossland, H&rft.au=Williams, J&rft.au=Loughna, P&rft.au=Churchward-Venne, TA&rft.au=Breen, L&rft.au=Phillips, SM&rft.au=Etheridge, T&rft.au=Rathmacher, JA&rft.au=Smith, K&rft.au=Szewczyk, NJ&rft.au=Atherton, PJ&rft_id=https://core.ac.uk/download/files/80/20023706.pdf&rfr_id=info:sid/en.wikipedia.org:Fractional synthetic rate" class="Z3988">