Flavokavain B

Flavokavain B
Names
	Preferred IUPAC name 2′-Hydroxy-4′,6′-dimethoxychalcone
	Other names Flavokawain B
Identifiers
CAS Number	1775-97-9 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	2059845
PubChem CID	5356121;
UNII	R9WC6SM4UQ ;
CompTox Dashboard (EPA)	DTXSID601028794 ;
	SMILES O=C(C2=C(O)C=C(OC)C=C2OC)/C=C/C1=CC=CC=C1;
Properties
Chemical formula	C17H16O4
Molar mass	284.311 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Flavokavain B is a flavokavain found in the kava plant.^[1] In 2010 a paper was published identifying it as a glutathione-depleting hepatotoxin.^[2]

FKB is said by enthusiasts to occur at higher concentrations in "tudei" kava strains, which are generally considered less desirable.

References

^ Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
^ Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)

External links

Flavokawain B at the United States National Library of Medicine

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[Dharmaratne_2002-01-30-1] Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.

[2] Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)

[1]

[2]

Flavokavain B

See also

References

External links