FGI-103

FGI-103
Legal status
Legal status	US: Investigational New Drug;
Identifiers
	IUPAC name 2-[(E)-2-(5-carbamimidoyl-1-benzofuran-2-yl)ethenyl]-3H-benzimidazole-5-carboximidamide;
CAS Number	907169-69-1 ;
PubChem CID	5477931;
ChemSpider	4585571;
UNII	B14V493D7B;
Chemical and physical data
Formula	C19H16N6O
Molar mass	344.378 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N=C(N)c4ccc3oc(C=Cc2nc1cc(C(=N)N)ccc1[nH]2)cc3c4;
	InChI InChI=1S/C19H16N6O/c20-18(21)10-2-5-16-12(7-10)8-13(26-16)3-6-17-24-14-4-1-11(19(22)23)9-15(14)25-17/h1-9H,(H3,20,21)(H3,22,23)(H,24,25)/b6-3 ; Key:OOKWWPFCCCMWIS-ZZXKWVIFSA-N;

FGI-103 is an antiviral drug developed as a potential treatment for the filoviruses Ebola virus and Marburg virus. In tests on mice FGI-103 was effective against both Ebola and Marburg viruses when administered up to 48 hours after infection. The mechanism of action of FGI-103 has however not yet been established, as it was found not to be acting by any of the known mechanisms used by similar antiviral drugs.^[1]^[2]^[3]

References

^ Warren TK, Warfield KL, Wells J, Enterlein S, Smith M, Ruthel G, et al. (May 2010). "Antiviral activity of a small-molecule inhibitor of filovirus infection". Antimicrobial Agents and Chemotherapy. 54 (5): 2152–9. doi:10.1128/AAC.01315-09. PMC 2863630. PMID 20211898.
^ Bradfute SB, Warfield KL, Bray M (September 2012). "Mouse models for filovirus infections". Viruses. 4 (9): 1477–508. doi:10.3390/v4091477. PMC 3499815. PMID 23170168.
^ De Clercq E (January 2015). "Ebola virus (EBOV) infection: Therapeutic strategies". Biochemical Pharmacology. 93 (1): 1–10. doi:10.1016/j.bcp.2014.11.008. PMC 7110990. PMID 25481298.

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[1] Warren TK, Warfield KL, Wells J, Enterlein S, Smith M, Ruthel G, et al. (May 2010). "Antiviral activity of a small-molecule inhibitor of filovirus infection". Antimicrobial Agents and Chemotherapy. 54 (5): 2152–9. doi:10.1128/AAC.01315-09. PMC 2863630. PMID 20211898.

[2] Bradfute SB, Warfield KL, Bray M (September 2012). "Mouse models for filovirus infections". Viruses. 4 (9): 1477–508. doi:10.3390/v4091477. PMC 3499815. PMID 23170168.

[3] De Clercq E (January 2015). "Ebola virus (EBOV) infection: Therapeutic strategies". Biochemical Pharmacology. 93 (1): 1–10. doi:10.1016/j.bcp.2014.11.008. PMC 7110990. PMID 25481298.

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[2]

[3]

Legal status

Legal status	US: Investigational New Drug
Identifiers
IUPAC name 2-[(E)-2-(5-carbamimidoyl-1-benzofuran-2-yl)ethenyl]-3H-benzimidazole-5-carboximidamide
CAS Number	907169-69-1^Y
PubChem CID	5477931
ChemSpider	4585571
UNII	B14V493D7B
Chemical and physical data
Formula	C₁₉H₁₆N₆O
Molar mass	344.378 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N=C(N)c4ccc3oc(C=Cc2nc1cc(C(=N)N)ccc1[nH]2)cc3c4
InChI InChI=1S/C19H16N6O/c20-18(21)10-2-5-16-12(7-10)8-13(26-16)3-6-17-24-14-4-1-11(19(22)23)9-15(14)25-17/h1-9H,(H3,20,21)(H3,22,23)(H,24,25)/b6-3 Key:OOKWWPFCCCMWIS-ZZXKWVIFSA-N

FGI-103

See also

References